Original Article

Antimüllerian Hormone Levels Of Infants With Premature Thelarche


  • Nursel Muratoglu Sahin
  • Elvan Bayramoglu
  • Hatice Nursun Ozcan
  • Erdal Kurnaz
  • Meliksah Keskin
  • Senay Savas Erdeve
  • Semra Cetinkaya
  • Zehra Aycan

Received Date: 13.12.2018 Accepted Date: 08.03.2019 J Clin Res Pediatr Endocrinol 0;0(0):0-0 [e-Pub] PMID: 30859797


AMH levels in mini puberty are higher than prepubertal period. In this study we investigated AMH levels in infants with premature thelarche who were presumed to have prolonged mini puberty due to inadequate/late suppression of pubertal activation.


Forty five female infants between 1 and 3 years of age with premature thelarche were enrolled in the study and 37 healthy girls in the same age group were included in the study. Bone age, pelvic ultrasonography (USG) findings, LH (luteinizing hormone), FSH (follicle-stimulating hormone ), estradiol and AMH level of the patient group and serum AMH level of the control group were evaluated.


Serum AMH levels of premature thelarche [med: 1.66 ng/ml (11.85 pmol/L) min-max: 0.15-6.32 ng/ml (1.07-45.12 pmol/L)] were significantly lower than the control group's [med: 1.96 ng/ml (13.99 pmol/L) min-max: 0.60-8.49 ng/ml (4.28-60.64 pmol/L)] (p:0.025). AMH and FSH were negatively correlated (r:-0.360 p:0.015) in infants with premature thelarche. There was no correlation between AMH and uterine size, uterine volume, endometrium thickness, fundocervical ratio, over size, over volume, follicle size and follicle number.


This is the first study that investigates AMH levels in infants with premature thelarche. It was concluded that AMH may play a role of suppressing pubertal findings during the infancy and decreased AMH may cause premature thelarche in infants because detected AMH levels in infants with premature thelarche were less than compared to healthy controls and there exists a negative correlation between AMH and FSH.

Keywords: AMH, premature thelarche, infancy, mini-puberty