Original Article

Catch-up Growth in Prepubertal Children Treated for Juvenile Hypothyroidism and Growth Hormone Deficiency can be Modelled with a Monomolecular Function

10.4274/jcrpe.galenos.2020.2020.0130

  • Jan M. Wit
  • Theo C.J. Sas
  • Michael B. Rank
  • Paula van Dommelen

Received Date: 08.06.2020 Accepted Date: 06.09.2020 J Clin Res Pediatr Endocrinol 0;0(0):0-0 [e-Pub] PMID: 32936765

Background/aims:

We hypothesized that modelling catch-up growth (CUG) as developed for coeliac disease (CD), might also fit CUG in adequately treated children with juvenile hypothyroidism (JHT) or growth hormone deficiency (GHD).

Methods:

We used a monomolecular function for all available prepubertal data on height SDS minus target height SDS (adjHSDS) in children with JHT (n=20) and GHD (n=18) on a conventional (CoD) or high GH dose (HD), based either on a national height reference with an age cut-off of 10 (girls) and 12 (boys) years (Model 1) or prepubertal height reference values, if age(0) was ≥3, with no upper age limit (Model 2).

Results:

The models could be fitted in 83-90% of cases; in other cases the HSDS decreased after several measurements which violates the assumption of an irreversible growth process. In JHT, the rate constant (k) and adjHSDS(0) were lower than in CD (p=0.02), but adjHSDS(end) was similar. In GHD (model 1), k was lower than for CD (p=0.004) but similar to JHT, while adjHSDS(0) and adjHSDS(end) were similar to CD and JHT. Thus, the shape of CUG is similar for children with JHT and GHD, while children with CD had less growth deficit at start and a faster CUG. The differences in CUG parameters between GH dose subgroups did not reach statistical significance.

Conclusion:

Modelling CUG of prepubertal children with JHT and GHD can be used for assessing the adequacy of CUG and the influence of clinical treatment modalities on its speed and magnitude.

Keywords: Growth, catch-up growth, coeliac disease, growth hormone deficiency, hypothyroidism