Original Article

Evaluation of the Ovarian Reserve in Adolescents with Hashimoto's Thyroiditis Using Serum anti- Müllerian Hormone Levels

10.4274/jcrpe.0047

  • Ezgi Özalp Akın
  • Zehra Aycan

Received Date: 06.02.2018 Accepted Date: 15.05.2018 J Clin Res Pediatr Endocrinol 0;0(0):0-0 [e-Pub] PMID: 29764793

Objective:

This study aims to evaluate the ovarian reserve of the adolescent girls with Hashimoto’s thyroiditis (HT) with serum anti-müllerian hormone (AMH) levels and compare to healthy adolescents. It is hypothesized that HT decreases ovarian reserve and AMH levels are lower in the HT group.

Method:

Thirty HT patients aged between 10-18 years and 30 healthy girls as the control group are enrolled in this cross-sectional study. The mean serum AMH levels of the groups are compared using the Mann-Whitney U test.

Results:

There was no statistically significant difference between the patient and the control groups in terms of serum AMH levels. There was negative correlation between serum AMH and thyroid stimulating hormone (TSH) levels and no correlation between serum AMH and anti-thyroid peroxidase (anti-TPO) or antithyroglobulin (anti-Tg) levels.

Conclusions:

Ovarian reserve of the adolescents by means of serum AMH levels, is not affected by HT according to this study. It is possible that autoimmune damage to the ovaries takes time and adolescence period may be too early on the age spectrum to see the effects, follow up of the patients for reproductive abnormalities and prospective studies are recommended.

Keywords: Hashimoto’s thyroiditis, ovarian reserve, Anti-müllerian hormone, adolescents