Original Article

Evaluation of unfavorable cardiovascular and metabolic risk factors in children and young adults with haemophilia

10.4274/jcrpe.0292

  • Melek Yıldız
  • Nihal Özdemir
  • Hasan Önal
  • Başak Koç
  • Beyza Eliuz Tipici
  • Bülent Zülfikar

Received Date: 11.12.2018 Accepted Date: 23.12.2018 J Clin Res Pediatr Endocrinol 0;0(0):0-0 [e-Pub] PMID: 30582317

Objective:

Increased risk of unfavorable cardiovascular risk factors has been defined in the aging population of haemophilia however they were less investigated in young patients. The purpose of this study was to assess obesity, hypertension, metabolic variables, insulin resistance and metabolic syndrome in young patients with haemophilia (PwH).

Methods:

Forty-eight haemophilia A and B patients and 35 age and sex matched healthy controls were included. Anthropometric measurements, blood pressure, fasting glucose and insulin levels, serum lipids and dietary intakes were evaluated. According to the criteria of International Diabetes Federation for pediatric and adult age groups, metabolic syndrome was defined.

Results:

The mean age of PwH was 21 years (range, 6–40 years). Forty-six percent of the PwH ≥18 years-old were obese/overweight vs none <18 years old. Obesity was more prevalent in PwH with arthropathy (p=0.017). Seven percent of the PwH ≥10 and <18 years-old and 25% of ≥18 years old had metabolic syndrome. There was no difference in metabolic syndrome between PwH and controls >10 years-old (19.5% vs 10% respectively, p=0.34). Fifty percent of the PwH ≥18 years-old had elevated blood pressure or hypertension. Fasting blood glucose levels of PwH were higher compared to controls (p=0.02).

Conclusions:

Our study showed that obesity, hypertension and metabolic syndrome are frequent problems especially in PwH with arthropathy. Early prevention and management of overweight, obesity, and their sequelae must be addressed in clinical practice in order to maximize the overall health of the haemophilia population.

Keywords: haemophilia, obesity, hypertension, metabolic syndrome