Original Article

Liver Biochemical Abnormalities in Adolescent Patients with Turner Syndrome

10.4274/jcrpe.galenos.2019.2018.0271

  • Małgorzata Wójcik
  • Anna Ruszała
  • Dominika Januś
  • Jerzy B. Starzyk

Received Date: 12.11.2018 Accepted Date: 17.05.2019 J Clin Res Pediatr Endocrinol 0;0(0):0-0 [e-Pub] PMID: 31117336

Objective:

To investigate the prevalence of abnormal LFTs in children and adolescents with TS; to analyse LFTs changes and its clinical significance during several years of observation; to evaluate the potential impact of increased BMI and sex hormones replacemet therapy (HRT) on LFTs.

Methods:

The analysis included 100 girls with TS (age 4-16, the mean BMI SDS 0.63 [SD 1.53]; 44 on HRT) treated with human recombinant growth hormone. A longitudinal study included 81 patients (mean follow-up period: 4.31 years, SD 0.82).

Results:

Elevated LFTs were found in 34 % of patients (in 32% without HRT vs. in 36% on HRT). The relative risk of increased LFTs activity was not higher in obese vs. normal weight (OR 0.2; 95% CI 0.1-0.36,p=0.38 vs. OR 0.16; 95% CI 0.08-0.3, p=0.1). HRT did not increase the risk of abnormal LFTs activity (OR 0.8; 95% CI 0.5-1.2, p=0.37 vs. OR 0.7; 95% CI 0.4-1.1, p=0.27). During the follow-up period, no patient developed overt liver disease. There was no significant increase nor decrease of the abnormal LFTs frequency in the subsequent years of follow up.

Conclusions:

Constantly elevated LFTs in TS are common in children and adolescents with TS. However the causes and clinical significance remain unclear, this study show, that obesity and HRT do not increase the risk of elevated LFTs.

Keywords: Turner syndrome, children, liver, estrogen