Case Report

Magnesium and anti-phosphate treatment with bisphosphonates for Generalised Arterial Calcification of Infancy: a case report

10.4274/jcrpe.0204

  • Fatma Dursun
  • Tülay Atasoy Öztürk
  • Serçin Güven
  • Heves Kırmızıbekmez
  • Gülcan Seymen Karabulut
  • Sevinç Kalın
  • Betül Sözeri

Received Date: 08.08.2018 Accepted Date: 06.12.2018 J Clin Res Pediatr Endocrinol 0;0(0):0-0 [e-Pub] PMID: 30525344

Generalized arterial calcification of infancy (GACI) is a rare autosomal- recessive disorder characterized by calcification of the internal elastic lamina, fibrotic myointimal proliferation of muscular arteries, and resultant arterial stenosis. Treatment with bisphosphonates has been proposed as a means of reducing arterial calcifications in GACI patients, although there is no formalized treatment approach. The case reported here is a patient with severe GACI diagnosed at 3 months of age who had no response to bisphosphonate treatment, but clinically improved after the initiation of magnesium and anti-phosphate (calcium carbonate) treatments. In patients unresponsive to bisphosphonate, magnesium and anti-phosphate treatment can be attempted.

Keywords: Generalized arterial calcification, infant, treatment, magnesium, etidronate