Original Article

Relations of Macular Variability with Anthropometric Measurements, Metabolic Parameters and Inflammatory Markers in Children and Adolescents with Metabolic Syndrome: A Cross-Sectional Study

10.4274/jcrpe.galenos.2019.2019.0082

  • Hakan Öztürk
  • Bediz Özen
  • Gönül Çatlı
  • Bumin Dündar

Received Date: 13.06.2019 Accepted Date: 16.08.2019 J Clin Res Pediatr Endocrinol 0;0(0):0-0 [e-Pub]

Background:

Macular damage may be observed in obesity and metabolic syndrome (MetS) that lead to chronic subclinical inflammation and affect almost all organ systems.

Objectives:

The purpose of this study was to investigate the relations of macular variability with anthropometric measurements, metabolic parameters, and inflammatory markers in children and adolescents with MetS.

Methods:

Two hundred twenty-eyes of 62 obese and 48 healthy children and adolescents were included in the study. Bilateral macular retinal thickness (MRT) and macular retinal volume (MRV) were measured in all subjects using optical coherence tomography (OCT). Relations between mean MRT and MRV and age, auxological measurements, metabolic parameters and the neutrophil/lymphocyte ratio (NLR), the platelet/lymphocyte ratio (PLR), and the systemic immune-inflammatory index (SIII) were investigated.

Results:

No statistically significant difference was observed between the groups in terms of age, sex distribution (p>0.05). Mean MRT (r= -0.326, p=0.007) and MRV (r=-0.303, p=0.007) values in the obese group with MetS decreased as homeostasis model assessment insulin resistance (HOMA-IR) values increased. SIII values were higher in obese groups, but particularly in the obese subject with MetS, compared to the control group (p=0.021). The decrease in mean MRT (r= -0.544, p= 0.046) and MRV (r= -0.651, p=0.031) in the obese subjects with MetS was negatively correlated with NLR. Mean MRT and MRV decreased in all obese subjects as SIII increased (p<0.05).

Conclusion:

This is the first study to show that mean MRT and MRV values decrease as body mass index standard deviation scores (BMI-SDS) and waist circumference standard deviation scores (WC-SDS) increase in obese children and adolescents with MetS. NLR and SIII may be a marker of chronic inflammation in obese children with MetS and are associated with macular damage.

Keywords: Macular retinal thickness, macular retinal volume, metabolic syndrome, optical coherence tomography, pediatric obesity