Original Article

Is Waist-Height Ratio Associated with Thyroid Antibody Levels in Children with Obesity?


  • Bahar Ozcabi
  • Gurkan Tarcin
  • Esma Sengenc
  • Feride Tahmiscioglu Bucak
  • Oya Ercan
  • Ibrahim Murat Bolayirli
  • Olcay Evliyaoglu

Received Date: 21.07.2020 Accepted Date: 18.09.2020 J Clin Res Pediatr Endocrinol 0;0(0):0-0 [e-Pub] PMID: 33006550


Obesity is known to affect thyroid functions. Recently, waist-height ratio (WHtR) has been considered as a useful marker of subclinical hypothyroidism in obese cases, but its relation with thyroid autoimmunity still remains unclear. We evaluated the effect of body fat mass, WHtR, and metabolic parameters on thyroid autoantibody levels in children with obesity.


This is a cross-sectional study carried out with an obese (n=56, M/F:29/26) and a healthy group (n=38, M/F:19/19). All subjects underwent anthropometric measurements, laboratory investigations for thyroid function tests, thyroid peroxidase (TPO-ab) and thyroglobulin antibodies (Tg-ab), transaminase, blood glucose, insulin levels, and lipids after overnight fasting. Fat mass was estimated by multiple frequency bioimpedance analysis in the obese group, which was further divided into two subgroups according to the median of WHtR. All parameters were compared between the groups/subgroups.


In the obese group, weight, height, body mass index (BMI), free-triiodothyronine, thyrotropin, TPO-ab, insulin, LDL-cholesterol, total cholesterol, alanine aminotransferase levels, and HOMA-IR were significantly higher than the controls group (p<0.05 for all). Median of WHtR was 0.6 in the obese group. In the “WHtR >0.6” subgroup (n=28), weight, BMI, fat mass, TPO-ab, Tg-ab, insulin and triglyceride levels were higher than WHtR ≤0.6 subgroup (p<0.05). A positive correlation was obtained between Tg-ab and WHtR (rho=0.28, p=0.041).


Euthyroid children with obesity and a WHtR >0.6 are likely to have higher thyroid antibody levels, and Tg-ab levels have a positive correlation with WHtR, which reveals an association of central adiposity with thyroid autoantibody levels in these cases.

Keywords: Free thyroxine, Free triiyodotironin, Thyroglobulin antibody, Thyroid peroxidase antibody, Thyroid stimulating hormone, Waist-height ratio