Original Article

SLC30A8 Gene rs13266634 C/T Polymorphism in Type 1 Diabetes Children of Tamil Nadu, India


  • Ramasamy Thirunavukkarasu
  • Arthur Joseph Asirvatham
  • Ayyappan Chitra
  • Mariakuttikan Jayalakshmi

Received Date: 28.07.2018 Accepted Date: 07.09.2018 J Clin Res Pediatr Endocrinol 0;0(0):0-0 [e-Pub] PMID: 30197307


Zinc transporter 8 (ZnT8) is a multi-trans membrane protein situated in the insulin secretory granule of the islets of β-cells and is identified as a novel auto-antigen in Type 1 diabetes (T1D). The gene coding for ZnT8 (solute carrier family 30 member 8; SLC30A8) is located in Chromosome 8q24.11. In this work it is aimed to identify the association of SLC30A8 rs13266634 C/T gene polymorphism with T1D in chosen children of Tamil Nadu, India.


The family based study is made on 121 T1D patients and 214 of their family members as control. The SLC30A8 gene rs13266634 C/T polymorphism is evaluated by polymerase chain reaction-restriction fragment length polymorphism (PCR–RFLP).


No significant differences was observed in allele (OR=0.92; CI=0.33 - 2.58; p=0.88) and genotype (CC: p=0.74; CT: p=0.82; TT: p=0.80) frequencies of rs13266634 C/T between T1D patients and controls. Transmission disequilibrium test (TDT) has identified over-transmission of mutant T allele from parents to affected children (T: U = 9:7) without statistical significance. Metaanalysis on the overall effects of rs13266634 C allele frequency was not different (p=0.10 and P heterogeneity = 0.99) in T1D patients upon comparison with control.


The present study along with the meta-analysis does not show any substantial association of the rs13266634 C/T polymorphism with T1D development.

Keywords: Type 1 diabetes,auto-antigen,polymorphisms,zinc transporter 8 Autoantibody,meta-analysis