Original Article

Nationwide study of Turner syndrome in children of Ukraine: analyses of the prevalence, genetic variants and phenotypic features
  • Nataliya Zelinska
  • Iryna Shevchenko
  • Evgenia Globa
J Clin Res Pediatr Endocrinol 0; 0: 0-0 [e-Pub] DOI: 10.4274/jcrpe.5119 PMID:29537378
Prospective Follow-up of Children with Idiopathic Growth Hormone Deficiency After Termination of Gh Treatment: Is There Really Need for Treatment at Transition to Adulthood?
  • Emine ÇAMTOSUN
  • Zeynep ŞIKLAR
  • Merih BERBEROĞLU
J Clin Res Pediatr Endocrinol 0; 0: 0-0 [e-Pub] DOI: 10.4274/jcrpe.0010 PMID:29553045
Prevalence and Related Factors of Euthyroid Sick Syndrome in Children with Untreated Cancer According to Two Different Criteria
  • Ali Duyu
  • Elvan Çağlar Çıtak
  • Erdem Ak
  • Serhan Kupeli
  • Begül Yağcı Küpeli
  • İbrahim Bayram
  • Gülay Sezgin
  • Gülçin Eskendari
  • Kerem Sezer
J Clin Res Pediatr Endocrinol 0; 0: 0-0 [e-Pub] DOI: 10.4274/jcrpe.0015 PMID:29553046
Insulin Resistance is Related to Psychiatric Disorders Among Obese Children
  • Deniz Özalp Kızılay
  • Şermin Yalın Sapmaz
  • Semra Şen
  • Yekta Özkan
  • Betül Ersoy
J Clin Res Pediatr Endocrinol 0; 0: 0-0 [e-Pub] DOI: 10.4274/jcrpe.0055 PMID:29789273
Incidence of Type 1 Diabetes in Children Aged Below 18 Years During 2013-2015 in Northwest Turkey
  • Şükran Poyrazoğlu
  • Rüveyde Bundak
  • Zehra Yavaş Abalı
  • Hasan Önal
  • Sevil Sarıkaya
  • Abdurrahman Akgün
  • Serpil Baş
  • Saygın Abalı
  • Abdullah Bereket
  • Erdal Eren
  • Ömer Tarım
  • Ayla Güven
  • Metin Yıldız
  • Derya Karaman Aksakal
  • Ayşegül Yüksel
  • Gülcan Seymen Karabulut
  • Şükrü Hatun
  • Tolga Özgen
  • Yaşar Cesur
  • Mehmet Azizoğlu
  • Emine Dilek
  • Filiz Tütüncüler
  • Esra Papatya Çakır
  • Bahar Özcabı
  • Olcay Evliyaoğlu
  • Songül Karadeniz
  • Fatma Dursun
  • Semih Bolu
  • İlknur Arslanoğlu
  • Gül Yeşiltepe Mutlu
  • Heves Kırmızıbekmez
  • Pınar İşgüven
  • Ala Üstyol
  • Erdal Adal
  • Ahmet Uçar
  • Nurcan Cebeci
  • Didem Bezen
  • Çigdem Binay
  • Serap Semiz
  • Hüseyin Anıl Korkmaz
  • Nihal Memioğlu
  • Elif Sagsak
  • Havva Nur Peltek
  • Melek Yıldız
  • Teoman Akçay
  • Serap Turan
  • Tülay Güran
  • Zeynep Atay
  • Neşe Akcan
  • Filiz Çizmecioğlu
  • Oya Ercan
  • Aydilek Dağdeviren
  • Firdevs Baş
  • Halim İşsever
  • Feyza Darendeliler
J Clin Res Pediatr Endocrinol 0; 0: 0-0 [e-Pub] DOI: 10.4274/jcrpe.0025 PMID:29789274
Effect of Telehealth System on Glycemic Control in Children and Adolescents with Type 1 Diabetes
  • Esra Döğer
  • Rukiye Bozbulut
  • A. Şebnem Soysal Acar
  • Şebnem Ercan
  • Aylin Kılınç Uğurlu
  • Emine Demet Akbaş
  • Aysun Bideci
  • Orhun Çamurdan
  • Peyami Cinaz
J Clin Res Pediatr Endocrinol 0; 0: 0-0 [e-Pub] DOI: 10.4274/jcrpe.0017 PMID:30015620
Efficacy and Safety of Continuous Subcutaneous Insulin Infusion vs. Multiple Daily Injections on Type 1 Diabetes Children Aged ≤ 18 Years Old, a Meta-Analysis with Randomized Control Trials
  • Yuan Qin
  • Lu-Hong Yang
  • Xiao-Li Huang
  • Xiao-Hong Chen
  • Hui Yao
J Clin Res Pediatr Endocrinol 0; 0: 0-0 [e-Pub] DOI: 10.4274/jcrpe.0053 PMID:30015622
Height, Weight and Body Mass Index Percentiles of Children Aged 6-14 Years Living at Moderate Altitudes
  • İsmail Malkoç
  • Mümtaz M. Mazıcıoğlu
  • Behzat Özkan
  • Meda Kondolot
  • Selim Kurtoğlu
  • Hakkı Yeşilyurt
J Clin Res Pediatr Endocrinol 2012; 4: 14-20 DOI: 10.4274/jcrpe.559 PMID:22394700
Neurocognitive Functions in Children and Adolescents with Subclinical Hypothyroidism
  • Ayça Törel Ergür
  • Yasemen Taner
  • Evşen Ata
  • Efnan Melek
  • Emel Erdoğan Bakar
  • Tanzer Sancak
J Clin Res Pediatr Endocrinol 2012; 4: 21-24 DOI: 10.4274/Jcrpe.497 PMID:22394701
Vitamin D Deficiency in Children and Adolescents
  • Nesibe Andıran
  • Nurullah Çelik
  • Halise Akça
  • Güzide Doğan
J Clin Res Pediatr Endocrinol 2012; 4: 25-29 DOI: 10.4274/jcrpe.574 PMID:22394709
The Effect of Insulin Resistance and Obesity on Low-Density Lipoprotein Particle Size in Children
  • Mehmet Emre Taşcılar
  • Tolga Özgen
  • Murat Cihan
  • Ayhan Abacı
  • Ediz Yeşilkaya
  • İbrahim Eker
  • Muhiddin Serdar
J Clin Res Pediatr Endocrinol 2010; 2: 63-66 DOI: 10.4274/jcrpe.v2i2.63 PMID:21274340
Need for Comprehensive Hormonal Workup in the Management of Adrenocortical Tumors in Children
  • E. Nazlı Gönç
  • Zeynep Alev Özön
  • Meltem Didem Çakır
  • Ayfer Alikaşifoğlu
  • Nurgün Kandemir
J Clin Res Pediatr Endocrinol 2014; 6: 68-73 DOI: 10.4274/jcrpe.1351 PMID:24932598
Growth of Children with Type 1 Diabetes Mellitus
  • Korcan Demir
  • Ayça Altıncık
  • Ayhan Abacı
  • Atilla Büyükgebiz
  • Ece Böber
J Clin Res Pediatr Endocrinol 2010; 2: 72-77 DOI: 10.4274/jcrpe.v2i2.72 PMID:21274342
Effects of Carbohydrate Counting Method on Metabolic Control in Children with Type 1 Diabetes Mellitus
  • Damla Gökşen
  • Yasemin Atik Altınok
  • Samim Özen
  • Günay Demir
  • Şükran Darcan
J Clin Res Pediatr Endocrinol 2014; 6: 74-78 DOI: 10.4274/jcrpe.1191 PMID:24932599
Fine-Needle Aspiration Biopsy in the Diagnosis and Follow-Up of Thyroid Nodules in Childhood
  • Ayça Altıncık
  • Korcan Demir
  • Ayhan Abacı
  • Ece Böber
  • Atilla Büyükgebiz
J Clin Res Pediatr Endocrinol 2010; 2: 78-80 DOI: 10.4274/jcrpe.v2i2.78 PMID:21274343
Identification of Novel ROR2 Gene Mutations in Indian Children with Robinow Syndrome
  • Parag M Tamhankar
  • Lakshmi Vasudevan
  • Shweta Kondurkar
  • Yashaswini K
  • Sunil Kumar Agarwalla
  • Mohandas Nair
  • Ramkumar TV
  • Nitin Chaubal
  • Vasundhara Sridhar Chennuri
J Clin Res Pediatr Endocrinol 2014; 6: 79-83 DOI: 10.4274/jcrpe.1233 PMID:24932600
Characteristics of Children with Type 1 Diabetes and Persistent Suboptimal Glycemic Control
  • Hyuntae Kim
  • Angelo Elmi
  • Celia L. Henderson
  • Fran R. Cogen
  • Paul B. Kaplowitz
J Clin Res Pediatr Endocrinol 2012; 4: 82-88 DOI: 10.4274/Jcrpe.663 PMID:22672865
Time Trends, Regional Variability and Seasonality Regarding the Incidence of Type 1 Diabetes Mellitus in Romanian Children Aged 0-14 Years, Between 1996 and 2015
  • Adrian Vlad
  • Viorel Serban
  • Anders Green
  • Sören Möller
  • Mihaela Vlad
  • Bogdan Timar
  • Alexandra Sima
  • on behalf of the ONROCAD Study Group
J Clin Res Pediatr Endocrinol 2018; 10: 92-99 DOI: 10.4274/jcrpe.5456 PMID:29082895
Lack of Association Between Peripheral Activity of Thyroid Hormones and Elevated TSH Levels in Childhood Obesity
  • Denisa Lobotková
  • Daniela Staníková
  • Juraj Staník
  • Ol’ga Cervenová
  • Vladimír Bzdúch
  • L’ubica Tichá
J Clin Res Pediatr Endocrinol 2014; 6: 100-104 DOI: 10.4274/Jcrpe.1251 PMID:24932603
The Effects of Six-Month L-Thyroxine Treatment on Cognitive Functions and Event-Related Brain Potentials in Children with Subclinical Hypothyroidism
  • Özlem Sangün
  • Serpil Demirci
  • Nihal Dündar
  • Özgür Pirgon
  • Tuğba Koca
  • Melike Doğan
  • Bumin Dündar
J Clin Res Pediatr Endocrinol 2015; 7: 102-108 DOI: 10.4274/jcrpe.1684 PMID:26316431
Prevalence of ZnT8 Antibody in Turkish Children and Adolescents with New Onset Type 1 Diabetes
  • Selin Elmaoğulları
  • Seyit Ahmet Uçaktürk
  • Şehri Elbeg
  • Esra Döğer
  • Meltem Tayfun
  • Fatih Gürbüz
  • Aysun Bideci
J Clin Res Pediatr Endocrinol 2018; 10: 108-112 DOI: 10.4274/jcrpe.5020 PMID:28943512
Evaluation of Pre-Treatment and Post-Treatment S100B, Oxidant and Antioxidant Capacity in Children with Diabetic Ketoacidosis
  • Cemil Kaya
  • Ali Ataş
  • Nurten Aksoy
  • Esra Celen Kaya
  • Mahmut Abuhandan
J Clin Res Pediatr Endocrinol 2015; 7: 109-113 DOI: 10.4274/jcrpe.1716 PMID:26316432
Retinal Neural and Vascular Structure in Isolated Growth Hormone Deficiency Children and Evaluation of Growth Hormone Treatment Effect
  • Özge Yüce
  • Nuriye Gökçen Yalçın
  • Aysun Bideci
  • Esra Döğer
  • Hamdi Cihan Emeksiz
  • Murat Hasanreisoğlu
  • Zeynep Aktaş
  • Orhun Çamurdan
  • Peyami Cinaz
J Clin Res Pediatr Endocrinol 2018; 10: 113-118 DOI: 10.4274/jcrpe.4758 PMID:29082892
Associations of Prenatal and Perinatal Factors with Cortisol Diurnal Pattern and Reactivity to Stress at Preschool Age Among Children Living in Poverty
  • Maha E. Elhassan
  • Alison L. Miller
  • Delia M. Vazquez
  • Julie C. Lumeng
J Clin Res Pediatr Endocrinol 2015; 7: 114-120 DOI: 10.4274/jcrpe.1685 PMID:26316433
Long-Term Treatment with n-3 Polyunsaturated Fatty Acids as a Monotherapy in Children with Nonalcoholic Fatty Liver Disease
  • Mehmet Boyraz
  • Özgür Pirgon
  • Bumin Dündar
  • Ferhat Çekmez
  • Nihal Hatipoğlu
J Clin Res Pediatr Endocrinol 2015; 7: 121-127 DOI: 10.4274/jcrpe.1749 PMID:26316434
Vitamin D Deficiency and Hashimoto’s Thyroiditis in Children and Adolescents: a Critical Vitamin D Level for This Association?
  • Olcay Evliyaoğlu
  • Manolya Acar
  • Bahar Özcabı
  • Ethem Erginöz
  • Feride Bucak
  • Oya Ercan
  • Mine Kucur
J Clin Res Pediatr Endocrinol 2015; 7: 128-133 DOI: 10.4274/jcrpe.2011 PMID:26316435
Restless Legs Syndrome and Poor Sleep Quality in Obese Children and Adolescents
  • Rıza Taner Baran
  • Müge Atar
  • Özgür Pirgon
  • Serkan Filiz
  • Meral Filiz
J Clin Res Pediatr Endocrinol 2018; 10: 131-138 DOI: 10.4274/jcrpe.5165 PMID:29175807
Vitamin D Deficiency in Children and Adolescents in Bağcılar, İstanbul
  • Meltem Erol
  • Özgül Yiğit
  • Suat Hayri Küçük
  • Özlem Bostan Gayret
J Clin Res Pediatr Endocrinol 2015; 7: 134-139 DOI: 10.4274/jcrpe.1888 PMID:26316436
Effectiveness of Continuous Subcutaneous Insulin Infusion Pump Therapy During Five Years of Treatment on Metabolic Control in Children and Adolescents with Type 1 Diabetes Mellitus
  • Özlem Korkmaz
  • Günay Demir
  • Hafize Çetin
  • İlkin Mecidov
  • Yasemin Atik Altınok
  • Samim Özen
  • Şükran Darcan
  • Damla Gökşen
J Clin Res Pediatr Endocrinol 2018; 10: 147-152 DOI: 10.4274/jcrpe.5117 PMID:29537377
Hyperinsulinemic Hypoglycemia: Experience in A Series of 17 Cases
  • Sebahat Yılmaz Ağladıoğlu
  • Şenay Savaş Erdeve
  • Semra Çetinkaya
  • Veysel Nijat Baş
  • Havva Nur Peltek Kendirci
  • Aşan Önder
  • Zehra Aycan
J Clin Res Pediatr Endocrinol 2013; 5: 150-155 DOI: 10.4274/Jcrpe.991 PMID:24072082
Thyroid Function in Obese Children with Non-Alcoholic Fatty Liver Disease
  • Hüseyin Bilgin
  • Özgür Pirgon
J Clin Res Pediatr Endocrinol 2014; 6: 152-157 DOI: 10.4274/jcrpe.1488 PMID:25241608
Intraoperative Parathyroid Hormone Monitoring Corroborates the Success of Parathyroidectomy in Children
  • Ahmet Çelik
  • Emre Divarcı
  • Zafer Dökümcü
  • Orkan Ergün
  • Samim Özen
  • Damla Gökşen
  • Şükran Darcan
  • Yeşim Ertan
J Clin Res Pediatr Endocrinol 2014; 6: 158-162 DOI: 10.4274/jcrpe.1401 PMID:25241609
Serum Paraoxonase/Arylesterase Activity and Oxidative Stress Status in Children with Metabolic Syndrome
  • Erdal Eren
  • Mahmut Abuhandan
  • Abdullah Solmaz
  • Abdullah Taşkın
J Clin Res Pediatr Endocrinol 2014; 6: 163-168 DOI: 10.4274/jcrpe.1454 PMID:25241610
Effects of ACE Inhibitors on Insulin Resistance and Lipid Profile in Children with Metabolic Syndrome
  • Eda Çelebi Bitkin
  • Mehmet Boyraz
  • Necati Taşkın
  • Arzu Akçay
  • Korkut Ulucan
  • Mehmet Bedir Akyol
  • Teoman Akçay
J Clin Res Pediatr Endocrinol 2013; 5: 164-169 DOI: 10.4274/Jcrpe.1020 PMID:24072084
Serum Adiponectin and hsCRP Levels and Non-InvasiveRadiological Methods in the Early Diagnosis ofCardiovascular System Complications in Children andAdolescents with Type 1 Diabetes Mellitus
  • Damla Gökşen
  • Ertürk Levent
  • Sakine Kar
  • Samim Özen
  • Şükran Darcan
J Clin Res Pediatr Endocrinol 2013; 5: 174-181 DOI: 10.4274/Jcrpe.1003 PMID:24072086
Elevated Urinary T Helper 1 Chemokine Levels in Newly Diagnosed Hypertensive Obese Children
  • Duygu Övünç Hacıhamdioğlu
  • Cengiz Zeybek
  • Faysal Gök
  • Aysel Pekel
  • Uğur Muşabak
J Clin Res Pediatr Endocrinol 2015; 7: 175-182 DOI: 10.4274/jcrpe.1917 PMID:26831550
Growth curves for Turkish Girls with Turner Syndrome: Results of the Turkish Turner Syndrome Study Group
  • Feyza Darendeliler
  • Ediz Yeşilkaya
  • Abdullah Bereket
  • Firdevs Baş
  • Rüveyde Bundak
  • Erkan Sarı
  • Banu Küçükemre Aydın
  • Şükran Darcan
  • Bumin Dündar
  • Muammer Büyükinan
  • Cengiz Kara
  • Mümtaz M. Mazıcıoğlu
  • Erdal Adal
  • Ayşehan Akıncı
  • Mehmet Emre Atabek
  • Fatma Demirel
  • Nurullah Çelik
  • Behzat Özkan
  • Bayram Özhan
  • Zerrin Orbak
  • Betül Ersoy
  • Murat Doğan
  • Ali Ataş
  • Serap Turan
  • Damla Gökşen
  • Ömer Tarım
  • Bilgin Yüksel
  • Oya Ercan
  • Şükrü Hatun
  • Enver Şimşek
  • Ayşenur Ökten
  • Ayhan Abacı
  • Hakan Döneray
  • Mehmet Nuri Özbek
  • Mehmet Keskin
  • Hasan Önal
  • Nesibe Akyürek
  • Kezban Bulan
  • Derya Tepe
  • Hamdi Cihan Emeksiz
  • Korcan Demir
  • Deniz Kızılay
  • Ali Kemal Topaloğlu
  • Erdal Eren
  • Samim Özen
  • Hüseyin Demirbilek
  • Saygın Abalı
  • Leyla Akın
  • Beray Selver Eklioğlu
  • Sultan Kaba
  • Ahmet Anık
  • Serpil Baş
  • Tolga Ünüvar
  • Halil Sağlam
  • Semih Bolu
  • Tolga Özgen
  • Durmuş Doğan
  • Esra Deniz Çakır
  • Yaşar Şen
  • Nesibe Andıran
  • Filiz Çizmecioğlu
  • Olcay Evliyaoğlu
  • Gülay Karagüzel
  • Özgür Pirgon
  • Gönül Çatlı
  • Hatice Dilek Can
  • Fatih Gürbüz
  • Çiğdem Binay
  • Veysel Nijat Baş
  • Celal Sağlam
  • Davut Gül
  • Adem Polat
  • Cengizhan Açıkel
  • Peyami Cinaz
J Clin Res Pediatr Endocrinol 2015; 7: 183-191 DOI: 10.4274/jcrpe.2023 PMID:26831551
Correlation of Brain Neuropeptide (Nesfatin-1 and Orexin-A) Concentrations with Anthropometric and Biochemical Parameters in Malnourished Children
  • Feyza Ustabaş Kahraman
  • Aysel Vehapoğlu
  • İlker Tolga Özgen
  • Şule Terzioğlu
  • Yaşar Cesur
  • Ruşen Dündaröz
J Clin Res Pediatr Endocrinol 2015; 7: 197-202 DOI: 10.4274/jcrpe.1930 PMID:26831553
Novel Growth Hormone-Releasing Hormone Receptor Gene Mutations in Turkish Children with Isolated Growth Hormone Deficiency
  • Ahmet Arman
  • Bumin Nuri Dündar
  • Ergun Çetinkaya
  • Nilüfer Erzaim
  • Atilla Büyükgebiz
J Clin Res Pediatr Endocrinol 2014; 6: 202-208 DOI: 10.4274/jcrpe.1518 PMID:25541890
Mitochondrial ATPase Subunit 6 and Cytochrome B Gene Variations in Obese Turkish Children
  • Durkadın Demir
  • Doğa Türkkahraman
  • Anıl Aktaş Samur
  • Güven Lüleci
  • Sema Akçurin
  • Özgül M. Alper
J Clin Res Pediatr Endocrinol 2014; 6: 209-215 DOI: 10.4274/jcrpe.1601 PMID:25541891
Arm Anthropometry Indices in Turkish Children and Adolescents: Changes Over a Three-Year Period
  • Betül Çiçek
  • Ahmet Öztürk
  • Mustafa Mümtaz Mazıcıoğlu
  • Selim Kurtoğlu
J Clin Res Pediatr Endocrinol 2014; 6: 216-226 DOI: 10.4274/jcrpe.1574 PMID:25541892
Assessment of Cardiovascular Parameters in Obese Children and Adolescents with Non-Alcoholic Fatty Liver Disease
  • Beray Selver Eklioğlu
  • Mehmet Emre Atabek
  • Nesibe Akyürek
  • Hayrullah Alp
J Clin Res Pediatr Endocrinol 2015; 7: 222-227 DOI: 10.4274/jcrpe.1949 PMID:26831557
Prevalence of Dyslipidemia and Associated Factors in Obese Children and Adolescents
  • Selin Elmaoğulları
  • Derya Tepe
  • Seyit Ahmet Uçaktürk
  • Fatma Karaca Kara
  • Fatma Demirel
J Clin Res Pediatr Endocrinol 2015; 7: 228-234 DOI: 10.4274/jcrpe.1867 PMID:26831558
Growth Patterns of Children of Same Geographic Background Reared in Different Environments
  • Sevil Arı Yuca
  • Yaşar Cesur
  • Selim Kurtoğlu
  • Mustafa Mümtaz Mazıcıoğlu
  • Emine Ayça Cimbek
J Clin Res Pediatr Endocrinol 2014; 6: 233-237 DOI: 10.4274/jcrpe.1612 PMID:25541894
The Effect of L-Thyroxine Treatment on Hypothyroid Symptom Scores and Lipid Profile in Children with Subclinical Hypothyroidism
  • Gönül Çatlı
  • Ahmet Anık
  • Hale Ünver Tuhan
  • Ece Böber
  • Ayhan Abacı
J Clin Res Pediatr Endocrinol 2014; 6: 238-244 DOI: 10.4274/jcrpe.1594 PMID:25541895
The Effects of Passive Smoking on the Six-Minute Walk Test in Obese Pediatric Cases
  • Nazan Kaymaz
  • Şule Yıldırım
  • Mustafa Tekin
  • Hakan Aylanç
  • Fatih Battal
  • Naci Topaloğlu
  • Fatih Binnetoğlu
  • Ayla Akbal
J Clin Res Pediatr Endocrinol 2014; 6: 245-249 DOI: 10.4274/jcrpe.1524 PMID:25541896
Diagnostic Work-up and Follow-up in Children with Tall Stature: A Simplified Algorithm for Clinical Practice
  • Susanne E. Stalman
  • Anke Pons
  • Jan M. Wit
  • Gerdine A. Kamp
  • Frans B. Plötz
J Clin Res Pediatr Endocrinol 2015; 7: 260-267 DOI: 10.4274/jcrpe.2220 PMID:26777036
The Effect of Vitamin D Treatment on Serum Adiponectin Levels in Children with Vitamin D Deficiency Rickets
  • Behzat Özkan
  • Hakan Döneray
  • Halil Keskin
J Clin Res Pediatr Endocrinol 2009; 1: 262-265 DOI: 10.4274/jcrpe.v1i6.262 PMID:21274306
Neutrophil Gelatinase-Associated Lipocalin as an Early Sign of Diabetic Kidney Injury in Children
  • Zeynep Yürük Yıldırım
  • Ahmet Nayır
  • Alev Yılmaz
  • Asuman Gedikbaşı
  • Rüveyde Bundak
J Clin Res Pediatr Endocrinol 2015; 7: 274-279 DOI: 10.4274/jcrpe.2002 PMID:26777038
Reference Values for Weight, Height, Head Circumference, and Body Mass Index in Turkish Children
  • Olcay Neyzi
  • Rüveyde Bundak
  • Gülbin Gökçay
  • Hülya Günöz
  • Andrzej Furman
  • Feyza Darendeliler
  • Firdevs Baş
J Clin Res Pediatr Endocrinol 2015; 7: 280-293 DOI: 10.4274/jcrpe.2183 PMID:26777039