Original Article

Investigating the Efficiency of Vitamin D administration with Buccal Spray in the Treatment of Vitamin D Deficiency in Children and Adolescents


  • Özlem Nalbantoğlu
  • Sezer Acar
  • Gülçin Arslan
  • Özge Köprülü
  • Behzat Özkan

Received Date: 01.05.2021 Accepted Date: 19.05.2021 J Clin Res Pediatr Endocrinol 0;0(0):0-0 [e-Pub] PMID: 34109778


The aim of this study was to evaluate the efficiency of buccal spray form of vitamin D compared to single oral dose (stoss therapy) and oral drops therapy in the treatment of vitamin D deficiency.


Ninety healthy children and adolescents (3-18 years) with vitamin D deficiency [serum level of 25-hydroxyvitamin D (25OHD) < 12ng/ml] were randomized to receive vitamin D3 buccal spray (2000 U, n=30, group I) for 6-week period, oral drops (2000 U, n=30, group II) for 6-week period and a single oral dose (300 000 U) vitamin D 3 (n=30, group III). Serum calcium, phosphorus, ALP, PTH and 25OHD levels of the patients were measured at baseline and after the treatment (42th day).


All 3 groups had a significant increase in serum 25 hydroxyvitamin D (25OHD) concentrations (p<0.001). Serum 25OHD concentration in group I was 22.1 (17.8-28.2) ng/ml as compared to baseline value of 8.0±0.41ng/ml, with the mean increase of 15.6±1.3 ng/ml. On the other hand, in group II and group III, the mean serum 25OHD concentrations were 24.4 (20.6-29.6) ng/ml and 40.3 (29.4-58.4) ng/ml as compared to baseline value of 7.9±0.45 ng/ml and 7.6±0.47 ng/ml, with the mean increase of 17.3±1.1ng/ml, 34.3±3.2 ng/ml, respectively.


We conclude that vitamin D3 supplementation with buccal spray and oral drops is equally effective in terms of raising vitamin D concentrations in short-term treatment of vitamin D deficiency.

Keywords: Vitamin D, buccal spray, 25-hydroxyvitamin D, oral drops