Controversies in the Definition and Treatment of Idiopathic Short Stature (ISS)
PDF

Review

Controversies in the Definition and Treatment of Idiopathic Short Stature (ISS)

J Clin Res Pediatr Endocrinol 2009;1(3):105-115 DOI: 10.4008/jcrpe.v1i3.53
, , ,
PDF
Permissions

Abstract

The term idiopathic short stature (ISS) refers to short children with no identifiable disorder of the growth hormone (GH)/insulin like growth factor (IGF) axis and no other endocrine, genetic or organ system disorder. This heterogeneous group of short children without GH deficiency (GHD) includes children with constitutional delay of growth and puberty, familial short stature, or both, as well as those with subtle cartilage and bone dysplasias. In rare cases, ISS is due to IGF molecular abnormalities. In this review we tackle the major challenges in the definition and treatment of ISS.

Keywords: growth, Idiopathic short stature, growth hormone, insulin-like growth factor

Read the full text

PDF

Create your free account to read the full text.

  • Full text with figures and tables
  • PDF and supplementary files
  • Access on every Galenos journal
Get free access

Already have an account?

Sign in
or
Continue with Google

One Galenos account works on every Galenos journal site.