Abstract
Objective
Neudesin is a newly discovered protein mainly secreted from adipose tissue and the brain. It plays a role as a neurotrophic factor in the brain and a negative regulator of energy expenditure. Neurodevelopmental delay and cognitive dysfunction are common features in cases with congenital hypothyroidism (CH) without treatment. Given the role of neudesin in brain development and its contribution to the survival of mature neurons, the relationship between neudesin and thyroid hormone was evaluated in babies diagnosed with CH.
Methods
Babies aged between 2-4 weeks and diagnosed with CH and healthy controls of similar age were included. All patients were evaluated for thyroid hormones and plasma neudesin levels. The basal neudesin levels between the patient and control groups and the patients’ neudesin levels before and after l-thyroxine treatment were compared.
Results
Fifty-two babies [32 with CH, 14 (44%) female, aged 19±7 days and 20 healthy controls, 7 (35%) female, aged 22±8 days] were included. There was no significant difference in baseline neudesin between the CH and control groups (6.77±6.41 vs. 7.93±7.04 ng/mL, respectively; p=0.552). However, neudesin levels increased significantly following one month of therapy in the CH group [median: 3.93 (minimum: 0.31, maximum: 30.06) vs. median: 6.15 (minimum: 2.17, maximum: 70.05) ng/mL, p=0.019].
Conclusion
Although there was no difference in baseline neudesin levels between the patient and control groups, neudesin levels increased after short-term treatment. Larger prospective studies are needed to understand the pathophysiological role of neudesin in untreated and treated early CH.
Keywords: Congenital hypothyroidism, neudesin, levothyroxine sodium
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References
van Trotsenburg P, Stoupa A, Léger J, Rohrer T, Peters C, Fugazzola L, Cassio A, Heinrichs C, Beauloye V, Pohlenz J, Rodien P, Coutant R, Szinnai G, Murray P, Bartés B, Luton D, Salerno M, de Sanctis L, Vigone M, Krude H, Persani L, Polak M. Congenital hypothyroidism: a 2020-2021 Consensus Guidelines update-an ENDO-European Reference Network Initiative Endorsed by the European Society for Pediatric Endocrinology and the European Society for Endocrinology. Thyroid. 2021;31:387-419.
Chen CY, Lee KT, Lee CT, Lai WT, Huang YB. Epidemiology and clinical characteristics of congenital hypothyroidism in an Asian population: a nationwide population-based study. J Epidemiol. 2013;23:85-94. Epub 2012 Dec 29.
Raza H, Riaz S, Jamal M, Shirazi H, Gul S. Congenital hypothyroidism newborn screening-the PIMS experience. Ann Pak Inst Med Sci. 2013;9:198-200.
Beardsall K, Ogilvy-Stuart AL. Congenital hypothyroidism. Current Paediatrics 2004;14:422-429.
LaFranchi SH, Austin J. How should we be treating children with congenital hypothyroidism? J Pediatr Endocrinol Metab. 2007;20:559-578.
Bowden SA, Goldis M. Congenital hypothyroidism. 2023 Jun 5. In: StatPearls [Internet]. Available from: https://pubmed.ncbi.nlm.nih.gov/32644339/
Koibuchi N, Chin WW. Thyroid hormone action and brain development. Trends Endocrinol Metab. 2000;11:123-128.
Oppenheimer JH, Schwartz HL. Molecular basis of thyroid hormone-dependent brain development. Endocr Rev. 1997;18:462-475.
Kimura I, Yoshioka M, Konishi M, Miyake A, Itoh N. Neudesin, a novel secreted protein with a unique primary structure and neurotrophic activity. J Neurosci Res. 2005;79:287-294.
Kimura I, Konishi M, Asaki T, Furukawa N, Ukai K, Mori M, Hirasawa A, Tsujimoto G, Ohta M, Itoh N, Fujimoto M. Neudesin, an extracellular heme-binding protein, suppresses adipogenesis in 3T3-L1 cells via the MAPK cascade. Biochem Biophys Res Commun. 2009;381:75-80.
Kimura I, Nakayama Y, Zhao Y, Konishi M, Itoh N. Neurotrophic effects of neudesin in the central nervous system. Front Neurosci. 2013;7:111.
Ohta H Itoh N. The membrane-associated progesterone receptor [MAPR] protein family. Curr Top Biochem Res. 2012;14:11-15.
Omuse G, Kawalya D, Mugaine P, Chege A, Maina D. Neonatal reference intervals for thyroid stimulating hormone and free thyroxine assayed on a Siemens Atellica® IM analyzer: a cross sectional study. BMC Endocr Disord. 2023;23:112.
Yajima H, Amano I, Ishii S, Sadakata T, Miyazaki W, Takatsuru Y, Koibuchi N. Absence of thyroid hormone ınduced delayed dendritic arborization in mouse primary hippocampal neurons through insufficient expression of brain-derived neurotrophic factor. Front Endocrinol (Lausanne). 2021;12:629100.
Sui L, Ren WW, Li BM. Administration of thyroid hormone increases reelin and brain-derived neurotrophic factor expression in rat hippocampus in vivo. Brain Res. 2010;1313:9-24.
Lasley SM, Gilbert ME. Developmental thyroid hormone insufficiency reduces expression of brain-derived neurotrophic factor (BDNF) in adults but not in neonates. Neurotoxicol Teratol. 2011;33:464-472.
Ohta H, Konishi M, Kobayashi Y, Kashio A, Mochiyama T, Matsumura S, Inoue K, Fushiki T, Nakao K, Kimura I, Itoh N. Deletion of the neurotrophic factor neudesin prevents diet-induced obesity by increased sympathetic activity. Sci Rep. 2015;5:10049.
Kratochvilova H, Lacinova Z, Klouckova J, Kavalkova P, Cinkajzlova A, Trachta P, Krizova J, Benes M, Dolezalova K, Fried M, Vlasakova Z, Pelikanova T, Spicak J, Mraz M, Haluzik M. Neudesin in obesity and type 2 diabetes mellitus: the effect of acute fasting and weight reducing interventions. Diabetes Metab Syndr Obes. 2019;12:423-430.
Bozkaya G, Fenercioglu O, Demir İ, Guler A, Aslanipour B, Calan M. Neudesin: a neuropeptide hormone decreased in subjects with polycystic ovary syndrome. Gynecol Endocrinol. 2020;36:849-853. Epub 2020 Apr 21.
Polkowska A, Pasierowska IE, Pasławska M, Pawluczuk E, Bossowski A. Assessment of serum concentrations of adropin, afamin, and neudesin in children with type 1 diabetes. Biomed Res Int. 2019;2019:6128410.
Çelikkol A, Binay Ç, Ayçiçek Ö, Güzel S. Serum neudesin levels in obese adolescents. J Clin Res Pediatr Endocrinol. 2022;14:69-75. Epub 2021 Nov 15.
Mullur R, Liu YY, Brent GA. Thyroid hormone regulation of metabolism. Physiol Rev. 2014;94:355-382.
