J Clin Res Pediatr Endocrinol. 2013; 5(1): 44-49 | DOI: 10.4274/Jcrpe.789

High-Sensitivity C-Reactive Protein Levels and ?Metabolic Disorders in Obese and Overweight ?Children and Adolescents

Konstantinos Kitsios¹, Maria Papadopoulou², Konstantina Kosta², Nikolaos Kadoglou³, Maria Papagianni², Kiriaki Tsiroukidou^2
1G.Gennimatas” General Hospital, Department of Internal Medicine, Thessaloniki, Greece
²Aristotle University of Thessaloniki, Hippokration General Hospital, Third Department of Pediatrics, Thessaloniki, Greece
³Foundation of Biomedical Research, Academy of Athens, Athens, Greece

Objective: To evaluate the contribution of cytotoxic T-Iymphocyte antigen-4 (CTLA-4)+49A/G polymorphism to the susceptibility to type-1 diabetes (T1D) in Turkish children.
Methods: A case-control study was designed to include 91 Turkish children with T1D and 99 healthy controls. CTLA-4 (+99A/G) gene polymorphism typing was done by PCR amplification followed by restriction fragment length polymorphism method.
Results: The genotype and allele frequencies of the CTLA-4 (+99A/G) polymorphism in patients with T1D were not different from those in the controls (p>0.05). The allele frequency of G was 36.2% in patients with T1D, and 31.8% in controls (p>0.05). Additionally, this polymorphism was not associated with the clinical and laboratory characteristics of the patients with T1D (p>0.05).
Conclusions: Our case-control study suggests that the CTLA-4 (+99A/G) gene polymorphism is not associated with T1D in the Turkish population.

Keywords: High-sensitivity C-reactive protein, obesity, metabolic syndrome,\r\nimpaired glucose tolerance, liver diseas

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