ISSN: 1308-5727 | E-ISSN: 1308-5735
Volume : 15 Issue : 1 Year : 2024
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Abstracting & Indexing
Turkish Society for Pediatric Endocrinology and Diabetes
Specific Functions of Melanocortin 3 Receptor (MC3R) [J Clin Res Pediatr Endocrinol]
J Clin Res Pediatr Endocrinol. 2023; 15(1): 1-6 | DOI: 10.4274/jcrpe.galenos.2022.2022-5-21

Specific Functions of Melanocortin 3 Receptor (MC3R)

Tulin Yanik1, Seyda Tugce Durhan2
1Middle East Technical University, Department of Biological Sciences, Ankara, Turkey
2Middle East Technical University, Department of Biochemistry, Ankara, Turkey

Melanocortin 3 receptor (MC3R) is a G-protein coupled receptor which has been defined mostly as a regulator of the appetite/hunger balance mechanisms to date. In addition to its function regarding the weight gain and appetite control mechanisms of MC3R, recent studies have shown that MC3R controls growth, puberty, and circadian rhythms as well. Despite the drastic effects of MC3R deficiency in humans and other mammals, its cellular mechanisms are still under investigation. In this review paper, we aimed to point out the importance of MC3R regulations in three main areas: 1) its impact on weight and appetite control, 2) its role in the control of growth, puberty, and the circadian rhythm, and, 3) its protein-protein interactions and cellular mechanisms.

Keywords: Childhood obesity, melanocortin 3 receptor, circadian rhythm, appetite control

Corresponding Author: Tulin Yanik, Türkiye
Manuscript Language: English
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