ISSN: 1308-5727 | E-ISSN: 1308-5735
Volume: 16 Issue: 1 Year: 2024
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Abstracting & Indexing
Turkish Society for Pediatric Endocrinology and Diabetes
Developmental Defects of the Thyroid Gland: Relationship with Advanced Maternal Age [J Clin Res Pediatr Endocrinol]
J Clin Res Pediatr Endocrinol. 2012; 4(2): 72-75 | DOI: 10.4274/Jcrpe.560

Developmental Defects of the Thyroid Gland: Relationship with Advanced Maternal Age

Heves Kırmızıbekmez1, Ayla Güven1, Metin Yıldız1, Ayşe Nurcan Cebeci1, Fatma Dursun1
Göztepe Education And Training Hospital, Department Of Pediatric Endocrinology, İstanbul, Turkey

Objective: Developmental defects of the thyroid gland are the most frequent causes of permanent congenital hypothyroidism. This study aimed to investigate the epidemiological features of patients with thyroid dysgenesis (TD).
Methods: Medical records of 234 patients with TD followed between the years 2008 and 2010 were evaluated retrospectively. Diagnosis was made by ultrasonography.
Results: Of 234 patients, 120 (51.3%) were male and 114 (48.7%) were female. Male to female ratio was 1.08 and there were no significant differences in epidemiologic and clinical findings between girls and boys. One hundred eighty-three patients (78.2%) were diagnosed as hypoplasia, 35 (14.9%) as thyroid agenesis, 4 as ectopic thyroid gland and 12 as hemiagenesis. The mean maternal age of the group was 28.9±0.4 years (range 18 to 45 years), which is significantly higher than the recently reported mean maternal ages for Turkish women.
Conclusions: Advanced maternal age was more prevalent in patients with TD. Our clinical and epidemiologic findings suggested no evidence of sexual dimorphism.

Keywords: Permanent congenital hypothyroidism,thyroid dysgenesis,hypoplasia,maternal age

Heves Kırmızıbekmez, Ayla Güven, Metin Yıldız, Ayşe Nurcan Cebeci, Fatma Dursun. Developmental Defects of the Thyroid Gland: Relationship with Advanced Maternal Age. J Clin Res Pediatr Endocrinol. 2012; 4(2): 72-75
Manuscript Language: English
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