ISSN: 1308-5727 | E-ISSN: 1308-5735
Volume: 16 Issue: 1 Year: 2024
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Turkish Society for Pediatric Endocrinology and Diabetes
Congenital Hypothyroidism Due To Maternal Radioactive Iodine Exposure During Pregnancy [J Clin Res Pediatr Endocrinol]
J Clin Res Pediatr Endocrinol. 2012; 4(2): 111-113 | DOI: 10.4274/jcrpe.553

Congenital Hypothyroidism Due To Maternal Radioactive Iodine Exposure During Pregnancy

Selim Kurtoğlu1, Mustafa Ali Akın1, Ghaniya Daar2, Leyla Akın3, Şeyma Memur1, Levent Korkmaz1, Osman Baştuğ1, Selcan Yılmaz1
1Erciyes University Faculty of Medicine, Department of Pediatrics, Division of Neonatology, Kayseri, Turkey
2Nevşehir Government Hospital, Department of Pediatrics, Nevşehir, Turkey
3Erciyes University Faculty of Medicine, Department of Pediatric Endocrinology, Kayseri, Turkey

Radioactive iodine (RAI) is used effectively in the treatment of hyperthyroidism and thyroid cancer, but it is contraindicated during pregnancy. RAI treatment during pregnancy can lead to fetal hypothyroidism, mental retardation and increased malignancy risk in the infant. Pregnancy tests must be performed before treatment in all women of reproductive age. However, at times, RAI is being used before ruling out pregnancy.
We herein present a male newborn infant with congenital hypothyroidism whose mother was given a three-week course of methimazole therapy for her multiple hyperactive nodules and subsequently received 20 mCi RAI during the 12th week of her pregnancy. The patient was referred to our neonatology unit at age two weeks when his thyrotropin (TSH) level was reported to be high in the neonatal screening test. Physical examination was normal. Laboratory investigations revealed hypothyroidism (free triiodothyronine 1.55 pg/mL, free thyroxine 2.9 pg/mL, TSH 452 mU/L, thyroglobulin 20.1 ng/mL). The thyroid gland could not be visualized by ultrasonography. L-thyroxine treatment was initiated.

Keywords: Pregnancy,Hyperthyroidism,radioactive iodine,fetal hypothyroidism

Selim Kurtoğlu, Mustafa Ali Akın, Ghaniya Daar, Leyla Akın, Şeyma Memur, Levent Korkmaz, Osman Baştuğ, Selcan Yılmaz. Congenital Hypothyroidism Due To Maternal Radioactive Iodine Exposure During Pregnancy. J Clin Res Pediatr Endocrinol. 2012; 4(2): 111-113
Manuscript Language: English
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