ISSN: 1308-5727 | E-ISSN: 1308-5735
Volume: 14 Issue: 2 Year: 2022
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Abstracting & Indexing
Turkish Society for Pediatric Endocrinology and Diabetes
Analysis of Apoptotic, Сlinical, Laboratory Parameters in Type 1 Diabetes and Early Diabetic Nephropathy in Frame of Clustering and Potential Groups Evaluation for Additional Therapeutic Interventions [J Clin Res Pediatr Endocrinol]
J Clin Res Pediatr Endocrinol. Ahead of Print: JCRPE-06025 | DOI: 10.4274/jcrpe.galenos.2022.2022-1-21

Analysis of Apoptotic, Сlinical, Laboratory Parameters in Type 1 Diabetes and Early Diabetic Nephropathy in Frame of Clustering and Potential Groups Evaluation for Additional Therapeutic Interventions

Burlaka Ie.a.
Bogomolets National Medical University, Department of Pediatrics №4 (Kyiv, Ukraine, Lva Tolstogo street,10,01004)

INTRODUCTION: Objectives: Type 1 diabetes (T1D) is one of the most prevalent chronic illnesses diagnosed in childhood. Diabetic nephropathy (DN) is one of the commonest complication of T1D. There is a great need for complex analysis of apoptotic, clinical, laboratory parameters and specific treatment that arrests progression of DN based on individual approach. Analysis of apoptotic, clinical, laboratory criteria in T1D and early DN in frame of clustering and evaluation of potential groups for additional therapeutic interventions.
METHODS: Methods: A survey of 104 children (62 males, 42 females) with T1D and DN aged 2 to 17 years in Endocrinology unit of Clinical Pediatric Hospital №6 (Kyiv, Ukraine) done. Clinical data (age, gender, disease duration, blood pressure), conventional laboratory markers (complete blood count, serum cholesterol, Hb1Ac, GFR, MAU), markers of apoptosis (BcL-xL, caspase-3), transcriptional factor HIF-1alfa analyzed. Data processed using GraphPad Prism 9.0 Software for Windows (USA, San Diego, CA). P values <0.05 considered statistically significant.
RESULTS: Methods: A survey of 104 children (62 males, 42 females) with T1D and DN aged 2 to 17 years in Endocrinology unit of Clinical Pediatric Hospital №6 (Kyiv, Ukraine) done. Clinical data (age, gender, disease duration, blood pressure), conventional laboratory markers (complete blood count, serum cholesterol, Hb1Ac, GFR, MAU), markers of apoptosis (BcL-xL, caspase-3), transcriptional factor HIF-1alfa analyzed. Data processed using GraphPad Prism 9.0 Software for Windows (USA, San Diego, CA). P values <0.05 considered statistically significant.
DISCUSSION AND CONCLUSION: Conclusion: Thus, we hypothesize that T1D pediatric patients with increased PLT count, hyperfiltration and reduced anti-apoptotic defense may be a cornerstone group for therapeutic interventions, i.e. antioxidants along with optimal glycemic control. DN group found to have somewhat increased PLT count, high frequency of DKA episodes/year, high MAU, prominent increase in HIF level, prominent disturbances in apoptosis controlling factors BcL-xL and caspase-3 requires additional therapeutic interventions, i.e. antioxidants, anti-apoptotic effectors along with optimal glycemic control, management of hypertension and albuminuria.

Keywords: Early diabetic nephropathy, T1D, hypoxia, HIF-1 alfa, apoptosis, predictors



Corresponding Author: Burlaka Ie.a., Ukraine
Manuscript Language: English
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