ISSN: 1308-5727 | E-ISSN: 1308-5735
Volume: 14 Issue: 2 Year: 2022
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Abstracting & Indexing
Turkish Society for Pediatric Endocrinology and Diabetes
Cord Blood Levels of Spexin, Leptin, and Visfatin in Term Born Small, <i>Appropriate</i>, and Large for Gestational Age Infants and Their Association with Newborn Anthropometric Measurements [J Clin Res Pediatr Endocrinol]
J Clin Res Pediatr Endocrinol. Ahead of Print: JCRPE-07269 | DOI: 10.4274/jcrpe.galenos.2022.2022-4-24

Cord Blood Levels of Spexin, Leptin, and Visfatin in Term Born Small, Appropriate, and Large for Gestational Age Infants and Their Association with Newborn Anthropometric Measurements

Yücel Pekal1, Bayram Özhan2, Yaşar Enli3, Özmert M. A. Özdemir4, Hacer Ergin4
1Pediatrician, Pamukkale University, School of Medicine, Division of Pediatrics
2Associated Professor, Pamukkale University, School of Medicine, Division of PediatricEndocrinology
3Professor, Pamukkale University, School of Medicine, Division of Medical Biochemistry
4Professor, Pamukkale University, School of Medicine, Division of Neonatology

INTRODUCTION: It has been known for a long time that children born small for gestational age are endangered of future risk of obesity and associated comorbidities. To identify risk factors and novel biomarkers are needed for early detection and to improve preventive strategies. Spexin,which is a novel neuropeptide playing crucial roles in the regulation of obesity, and fat metabolism, is suggested a candidate biomarker for predicting obesity and related comorbidities at an early age. The aim of our study was to investigate serum levels of spexin in term born small, appropriate, and large for gestational age and its association with newborn anthropometric measurements.
METHODS: One hundred twenty term newborn babies classified as small for gestational age (SGA), appropriate for gestational age (AGA), or large for gestational age and their mothers were included in the study. Spexin along with leptin and visfatin were measured in umbilical cord and maternal serum by enzyme-linked immunosorbent assay.
RESULTS: Fifty-six (46.7%) neonates were girls and 64 (53.3%) were boys. The neonates’ mean birth weight was 3170.70±663 g, birth length was 48.9±2.79 cm, and head circumference was 34.5±1.67 cm. Birth weights, lengths, and head circumferences of the neonates in the SGA, AGA, and LGA groups were statistically different. Cord blood spexin and leptin levels in the SGA groups were significantly lower than those of both the LGA and AGA groups. Cord blood visfatin levels were significantly lower in the AGA group than the LGA and SGA groups. Maternal spexin levels of SGA babies were significantly lower than those of the mothers in both the LGA and AGA groups, but no significant difference was observed between the SGA and LGA groups. Maternal visfatin levels of the AGA babies were significantly higher than the maternal levels of SGA and LGA groups. There was no difference in terms of maternal leptin levels. Cord blood speksin and leptin levels were positively correlated to the birth weight, lenght and head circumference. Birth weight increased significantly in line with maternal pregestational BMI.
DISCUSSION AND CONCLUSION: The lowest SPX levels were determined in the SGA babies and cord spexin level was found to be significantly correlated with newborn length, weight, and head circumference.

Keywords: Adipokine, speksin, antropometry, newborn, umblical cord



Corresponding Author: Bayram Özhan, Türkiye
Manuscript Language: English
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