ISSN: 1308-5727 | E-ISSN: 1308-5735
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Turkish Society for Pediatric Endocrinology and Diabetes
The Relationship Between Metabolic Syndrome and Left Ventricular Mass Index in Obese Children [J Clin Res Pediatr Endocrinol]
J Clin Res Pediatr Endocrinol. 2011; 3(3): 132-138 | DOI: 10.4274/jcrpe.v3i3.26

The Relationship Between Metabolic Syndrome and Left Ventricular Mass Index in Obese Children

Mehmet Emre Atabek1, Beray Selver Eklioğlu1, Esra Akyüz2, Derya Çimen3
1Selçuk University School Of Medicine, Department Of Pediatric Endocrinology And Diabetes, Konya, Turkey
2Selçuk University School Of Medicine, Department Of Pediatrics, Konya, Turkey
3Selçuk University School Of Medicine, Department Of Pediatric Cardiology, Konya, Turkey

Objective: To investigate the relationships between metabolic syndrome (MS), other metabolic features and left ventricular mass index (LVMI) in a population of obese children and adolescents with MS.
Methods: Two hundred and eight obese children and adolescents (119 girls and 89 boys, mean age: 11.9±2.7 years) and control subjects (24 girls and 26 boys, mean age: 11.4±2.9 years) were enrolled in the study. The insulin sensitivity index and LVMI were determined. The International Diabetes Federation criteria were used to diagnose MS.
Results: The obese patients were divided into MS group (n = 55) and non-MS (n = 153) group. The values of LVMI in the MS group were significantly higher than those in the non-MS group (p = 0.014). The present LVMI cut-off point of 33g/m2 for the diagnosis of MS yielded a sensitivity of 97% and a specificity of 98%. LVMI was found to be positively correlated in univariate analysis with height, weight, body mass index (BMI)¬ SDS, fasting insulin level, homeostasis model assessment of insulin resistance (HOMA-IR) and fasting glucose insulin ratio (FGIR) and negatively correlated with quantitative insulin sensitivity check index (QUICK-I).
Conclusions: We suggest that our optimal LVMI cut-off value for identifying MS may be considered as a sensitive index in screening obese children and adolescents for pediatric MS. Assessment of LVMI in obese children and adolescents may be used as a tool in predicting the presence of MS and its associated cardiovascular risks.

Keywords: obesity,metabolic syndrome,cardiovascular disease,left ventricular mass index,children

Mehmet Emre Atabek, Beray Selver Eklioğlu, Esra Akyüz, Derya Çimen. The Relationship Between Metabolic Syndrome and Left Ventricular Mass Index in Obese Children. J Clin Res Pediatr Endocrinol. 2011; 3(3): 132-138
Manuscript Language: English
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