Prepubertal Unilateral Gynecomastia: Report of 2 Cases
Hüseyin Demirbilek1, Gökhan Bacak2, Rıza Taner Baran1, Yahya Avcı3, Ahmet Baran4, Ayşenur Keleş3, Mehmet Nuri Özbek1, Yasemin Alanay5, Khalid Hussain21Diyarbakır Children State Hospital, Clinic of Pediatric Endocrinology, Diyarbakır, Turkey2Great Ormond Street Hospital for Children, Clinic of Pediatric Endocrinology, London, United Kingdom
3University College, Institute of Child Health, London, United Kingdom
4Diyarbakır Training and Research Hospital, Clinic of Plastic and Reconstructive Surgery, Diyarbakır, Turkey
5Dicle University Faculty of Medicine, Department of Pathology, Diyarbakır, Turkey
Prepubertal unilateral gynecomastia is an extremely rare condition. At present, its etiology and management strategy are not well known. Two unrelated prepubertal boys of ages 8 and 9 who presented with complaints of unilateral enlargement of breast tissue are reported. Physical examination, biochemical, hormonal and oncologic work-up findings were normal. Both patients were treated with peripheral liposuction successfully. Histopathological and immunohistochemical examinations showed benign fibroglandular gynecomastia and intensive (3+) estrogen receptor expression in 100% of periductal epithelial cells. Although an extremely rare and generally benign condition, patients with prepubertal unilateral gynecomastia should have a full endocrine and oncologic work-up.
Keywords: gynecomastia,pubertal,prepubertal,unilateralManuscript Language: English
