ISSN: 1308-5727 | E-ISSN: 1308-5735
Volume: 15 Issue: 1 Year: 2023
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Turkish Society for Pediatric Endocrinology and Diabetes
Evaluation of Abnormal Uterine Bleeding in Adolescents: Single Center Experience [J Clin Res Pediatr Endocrinol]
J Clin Res Pediatr Endocrinol. Ahead of Print: JCRPE-37232 | DOI: 10.4274/jcrpe.galenos.2023.2022-10-7

Evaluation of Abnormal Uterine Bleeding in Adolescents: Single Center Experience

Sirmen Kızılcan Çetin1, Zehra Aycan2, Elif Özsu1, Zeynep Şıklar1, Ayşegül Ceran1, Seda Erişen Karaca1, Gizem Şenyazar1, Merih Berberoğlu1
1Ankara University, Faculty of Medicine, Department of Pediatric Endocrinology, Ankara, Turkey
2Ankara University, Faculty of Medicine, Department of Pediatric Endocrinology, Ankara, Turkey and Ankara University, Faculty of Medicine, Department of Adolescent Health, Ankara, Turkey

INTRODUCTION: Abnormal uterine bleeding (AUB) is adolescent girls' most common gynecologic complaint. This study aimed to determine the diagnostic and management differences between those with/without heavy menstrual bleeding.
METHODS: We collected retrospective data such as follow-up, final control, and treatment regimen of adolescents aged 10-19 with the diagnosis of AUB. We excluded adolescents with known bleeding disorders at admission. We classified all subjects according to the level of anemia. Group 1 consisted of subjects with heavy bleeding (Hb<10 g/dl), and the rest with moderate and mild bleeding (Hb>10 g/dl) presented in Group 2. Admission and follow-up characteristics between the two groups were compared.
RESULTS: In this study, we included 79 adolescent girls with a mean age was 14.3±1.8 years. 85% of all had a menstrual irregularity in the first two years after menarche. Anovulation was observed in 80%. 95% of group 1 had irregular bleeding in the two years (p<0.01). In all subjects, while 13 girls (16%) were diagnosed with PCOS, two adolescents (2%) had structural anomalies. No adolescents had hypothyroidism or hyperprolactinemia. Three (10.7%) were diagnosed with Factor 7 deficiency. Nineteen girls had MTHFR mutation. None had venous thromboembolism during at least six month-follow-up-period.
DISCUSSION AND CONCLUSION: This study showed that 85% of AUB had occurred in the first two years. We found the frequency of hematological disease (Factor 7 deficiency) 10.7%. The frequency of MTHFR mutation was 50%. We thought this did not increase the risk of bleeding/thrombosis. Its routine evaluation was not necessarily due to the similarity in population frequency.

Keywords: Abnormal uterine bleeding, adolescents, anovulatory bleeding, heavy menstrual bleeding



Corresponding Author: Sirmen Kızılcan Çetin, Türkiye
Manuscript Language: English
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