Ghrelin Levels and Postnatal Growth in Healthy Infants 0-3 Months of Age
Kürşad Fidancı1, Cihan Meral1, Selami Süleymanoğlu1, Özgür Pirgon2, Ferhan Karademir1, Seçil Aydınöz1, Halit Özkaya1, Mustafa Gültepe3, İsmail Göçmen11Department Of Pediatrics, Gata Medical Faculty, İstanbul, Turkey2Department Of Pediatric Endocrinology, Gata Medical Faculty, İstanbul, Turkey
3Department Of Biochemistry, Gata Medical Faculty, İstanbul, Turkey
Objective: The effect of ghrelin on growth of the newborn has long been argued, but not fully clarified. In this study, we aimed to investigate the relationship between ghrelin levels and growth parameters in the first 3 months of life.
Methods: The study included 60 babies (27 girls and 33 boys) born at gestational ages between 38-42 weeks. The newborns were divided into three groups according to the Lubchenco curves as: small for gestational age (SGA), appropriate for gestational age (AGA) and large for gestational age (LGA). The relationship between ghrelin levels and growth parameters in the third month was investigated.
Results: Ghrelin concentrations were significantly higher in SGA (2.4±2.6 ng/dL) babies than in AGA (1.3±0.9 ng/dL) and LGA (1.0±0.8 ng/dL) babies. The lowest ghrelin levels were in the LGA group. In SGA infants, ghrelin concentrations were inversely correlated with change in weight (r=-0.577; p=0.001), change in length (r=-0.361; p=0.005), and change in head circumference (r=-0.387; p=0.002).
Conclusion: The results show that at age 3 months, SGA infants had higher ghrelin levels than AGA and LGA infants. Our findings indicate that ghrelin may be involved in the process of catch-up growth in these infants.
Manuscript Language: English
