ISSN: 1308-5727 | E-ISSN: 1308-5735
Volume: 16 Issue: 1 Year: 2024
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Turkish Society for Pediatric Endocrinology and Diabetes
The Association between Serum 25-Hydroxy Vitamin D Level and Urine Cathelicidin in Children with a Urinary Tract Infection [J Clin Res Pediatr Endocrinol]
J Clin Res Pediatr Endocrinol. 2016; 8(3): 325-329 | DOI: 10.4274/jcrpe.2563

The Association between Serum 25-Hydroxy Vitamin D Level and Urine Cathelicidin in Children with a Urinary Tract Infection

Duygu Övünç Hacıhamdioğlu1, Demet Altun2, Bülent Hacıhamdioğlu1, Ferhat Çekmez1, Gökhan Aydemir1, Mustafa Kul1, Tuba Müftüoğlu3, Selami Süleymanoğlu1, Ferhan Karademir1
1Gülhane Military Medical Academy, Haydarpaşa Training And Research Hospital, Clinic Of Pediatrics, İstanbul, Turkey
2Etimesgut Military Hospital, Clinic Of Pediatrics, Ankara, Turkey
3Gülhane Military Medical Academy, Haydarpaşa Training And Research Hospital, Clinic Of Biochemistry, İstanbul, Turkey

Objective: Cathelicidin is an important antimicrobial peptide in the urinary tract. Cathelicidin expression is strongly stimulated by 1,25-dihydroxy vitamin D in epithelial cells, macrophages/monocytes, and neutrophils. Vitamin D and cathelicidin status in children with urinary tract infection (UTI) caused by Escherichia coli is unknown. To establish the relationship between serum vitamin D and urine cathelicidin levels in children with a UTI caused by Escherichia coli.
Methods: Serum 25-hydroxy vitamin D and urine cathelicidin levels were measured in 36 patients with UTI (mean age 6.8±3.6 years, range: 0.25-12.6 years) and 38 controls (mean age 6.3±2.8 years, range: 0.42-13 years).
Results: There were no significant differences in urine cathelicidin levels between the study and control groups (p>0.05). Eight (22.2%) patients in the study group and 21 (58.3%) children in the control group were found to have sufficient vitamin D (?20 ng/mL). Patients with sufficient vitamin D had higher urine cathelicidin levels than the controls with sufficient vitamin D (respectively 262.5±41.1 vs. 168±31.6 ng/mL, p=0.001). There were no significant differences between the patients and controls with insufficient vitamin D (p>0.05).
Conclusion: The children with vitamin D insufficiency may not be able to increase their urine cathelicidin level during UTI caused by Escherichia coli. There is a need of prospective studies in order to prove a beneficial effect of vitamin D supplementation for the restoration of cathelicidin stimulation and consequently for prevention of UTI recurrence.

Keywords: Urinary tract infection,Escherichia coli,children,Vitamin D,cathelicidin

Duygu Övünç Hacıhamdioğlu, Demet Altun, Bülent Hacıhamdioğlu, Ferhat Çekmez, Gökhan Aydemir, Mustafa Kul, Tuba Müftüoğlu, Selami Süleymanoğlu, Ferhan Karademir. The Association between Serum 25-Hydroxy Vitamin D Level and Urine Cathelicidin in Children with a Urinary Tract Infection. J Clin Res Pediatr Endocrinol. 2016; 8(3): 325-329
Manuscript Language: English
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