Heart-Type Fatty Acid Binding Protein Level as a Tool in Identification of Early Cardiac Effects of Diabetic Ketoacidosis
Fatma Hilal Yılmaz1, Sevil Arı Yuca2, Hüsamettin Vatansev3, Emine Ayça Cimbek2, Yaşar Şen2, İsa Yılmaz1, Fikret Akyürek3, Derya Arslan4, Derya Çimen5, Alaaddin Yorulmaz61Selçuk University Faculty Of Medicine, Department Of Child Health And Diseases, Konya, Turkey2Selçuk University Faculty Of Medicine, Department Of Pediatric Endocrinology, Konya, Turkey
3Selçuk University Faculty Of Medicine, Department Of Biochemistry, Konya, Turkey
4Konya Training And Research Hospital, Clinic Of Pediatric Cardiology, Konya, Turkey
5Selçuk University Faculty Of Medicine, Department Of Pediatric Cardiology, Konya, Turkey
6Beyhekim State Hospital, Clinic Of Child Health And Diseases, Konya, Turkey
Objective: This study aimed to measure the serum levels of heart-type fatty acid binding protein (H-FABP) in patients presenting with diabetic ketoacidosis (DKA) and diabetic ketosis (DK) and to determine its role in identifying early-period cardiac ischemia.
Methods: This prospective study included 35 patients diagnosed with DKA, 20 patients diagnosed with DK, and 20 control subjects. H-FABP, creatine kinase-MB (CK-MB), and troponin I levels were investigated at presentation in patients with DKA and DK and in the control group. H-FABP values were measured again after acidosis correction in the DKA patients.
Results: No statistically significant differences were found with respect to troponin I and CK-MB within the groups. The H-FABP values of DKA patients at presentation were found to be significantly higher than those of DK patients and the control group (p=0.015). The H-FABP value of the DKA group was also found to be significantly higher than the value at hour 36 after acidosis correction (p=0.0001).
Conclusion: We would like to propose H-FABP as a potential marker for indicating myocardial ischemia.
Manuscript Language: English
