ISSN: 1308-5727 | E-ISSN: 1308-5735
Volume: 16 Issue: 1 Year: 2024

Abstracting & Indexing
Turkish Society for Pediatric Endocrinology and Diabetes
Environmental Contaminants and Pancreatic Beta-Cells [J Clin Res Pediatr Endocrinol]
J Clin Res Pediatr Endocrinol. 2016; 8(3): 257-263 | DOI: 10.4274/jcrpe.2812

Environmental Contaminants and Pancreatic Beta-Cells

Gabriel Fabricio1, Ananda Malta2, Abalo Chango3, Paulo Cezar De Freitas Mathias4
1University Of Lille 1, Glycobiology Structural And Functional Unit, Villeneuve D’Ascq, France
2Capes-Foundation, Ministry Of Education Brazil, Brasilia, Brazil
4Capes-Foundation, Ministry Of Education Brazil, Brasilia, Brazil & State University Of Maringá, Department Of Cell Biology And Genetics, Laboratory Of Secretion Cell Biology, Maringá, Brazil

Despite health policies as well as clinical and research efforts, diabetes prevalence is still rising around the world. A multitude of causes have been suggested for this increase, mostly related to familial background, the occidental diet which is rich in fat/carbohydrates, and sedentary life style. Type 2 diabetes involves malfunctions of the primary pancreatic beta-cells, usually attributed to local damage; however, it can be associated with other stressful environmental agents, such as chemical contaminants from food, plastic and air, among others. Indeed, exposure to these chemical agents during perinatal and adolescent life can increase the risk of developing cardiometabolic diseases later in life. This review explores data showing which environmental chemical agents may produce injury in beta-cells and further impair the insulinotropic process of type 2 diabetes. Additionally, it points the need to also consider unusual causes of metabolic diseases, such as environmental contaminants.

Keywords: Contaminants,pancreatic beta-cell,Diabetes,insulin resistance

Gabriel Fabricio, Ananda Malta, Abalo Chango, Paulo Cezar De Freitas Mathias. Environmental Contaminants and Pancreatic Beta-Cells. J Clin Res Pediatr Endocrinol. 2016; 8(3): 257-263
Manuscript Language: English
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