ISSN: 1308-5727 | E-ISSN: 1308-5735
Volume: 16 Issue: 1 Year: 2024
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Turkish Society for Pediatric Endocrinology and Diabetes
The Role of Initial Clinical and Laboratory Findingsin Infants With Hyperthyrotropinemia to PredictTransient or Permanent Hypothyroidism [J Clin Res Pediatr Endocrinol]
J Clin Res Pediatr Endocrinol. 2013; 5(3): 170-173 | DOI: 10.4274/Jcrpe.931

The Role of Initial Clinical and Laboratory Findingsin Infants With Hyperthyrotropinemia to PredictTransient or Permanent Hypothyroidism

Tolga Ünüvar1, Korcan Demir2, Ayhan Abacı3, Atilla Büyükgebiz4, Ece Böber2
1Ünüvar
2Dokuz Eylül University Medical Faculty, Department Of Pediatric Endocrinology, İzmir, Turkey
3Dokuz Eylül University Faculty of Medicine, Department of Pediatric Endocrinology, İzmir, Turkey
4Bilim University, Department Of Pediatric Endocrinology, İstanbul, Turkey

Objective: Studies on the clinical course of children with hyperthyrotropinemia are scarce. We aimed to evaluate the role of presentation findings in such infants to predict eventual outcome.
Methods: Files of infants diagnosed as suspicious congenital hypothyroidism (CH) in the neonatal or early infancy period in the past ten years were analyzed retrospectively, and 37 patients (M/F: 20/17) with hyperthyrotropinemia diagnosed at a median age of 3.2 months were included in the study. Criteria for inclusion were: normal free thyroxine (fT4) levels and thyrotropin (TSH) levels between 10-20 µIU/mL during the initial neonatal screening (or TSH<10 µIU/mL afterwards). Cases with permanent CH (Group 1) were compared to those with transient hyperthyrotropinemia (Group 2) regarding age at the time of diagnosis, sex, gestational age, birth weight, symptoms, ultrasonographic and scintigraphic findings, initial thyroid function tests, and state of mental and motor development.
Results: Of the total group, 20 patients (54%) were eventually diagnosed as permanent CH. T4 doses that maintained normal thyroid function tests were significantly higher at the end of the first and second years of life in this group. Age, TSH and fT4 levels at the time of diagnosis, sex, gestational age, birth weight, symptoms, ultrasonographic and scintigraphic findings, and the state of mental and motor development were similar in the two groups.
Conclusions: T4 dose required to maintain a euthyroid state was the only parameter which distinguished between transient and permanent CH.

Keywords: Permanent congenital hypothyroidism,hyperthyrotropinemia,thyroxine,infant

Tolga Ünüvar, Korcan Demir, Ayhan Abacı, Atilla Büyükgebiz, Ece Böber. The Role of Initial Clinical and Laboratory Findingsin Infants With Hyperthyrotropinemia to PredictTransient or Permanent Hypothyroidism. J Clin Res Pediatr Endocrinol. 2013; 5(3): 170-173
Manuscript Language: English
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