ISSN: 1308-5727 | E-ISSN: 1308-5735
Volume: 16 Issue: 1 Year: 2024
Forms

Abstracting & Indexing
Turkish Society for Pediatric Endocrinology and Diabetes
Epidemiologic Features of Type 1 Diabetic Patients between 0 and 18 Years of Age in İstanbul City [J Clin Res Pediatr Endocrinol]
J Clin Res Pediatr Endocrinol. 2015; 7(1): 49-56 | DOI: 10.4274/jcrpe.1694

Epidemiologic Features of Type 1 Diabetic Patients between 0 and 18 Years of Age in İstanbul City

Fikri Demir1, Hülya Günöz2, Nurçin Saka2, Feyza Darendeliler2, Rüveyde Bundak2, Firdevs Baş2, Olcay Neyzi2
1Dicle University Faculty Of Medicine, Department Of Pediatrics, Diyarbakır, Turkey
2İstanbul University Faculty Of Medicine, Department Of Pediatric Endocrinology, İstanbul, Turkey

Objective: To evaluate the epidemiologic, clinical and laboratory characteristics of a group of children with type 1 diabetes mellitus (T1DM) living in a Turkish city.
Methods: The records of 395 (boys/girls: 199/196) children with newly diagnosed T1DM hospitalized in the years 1985-2004 were evaluated retrospectively. The data were assessed by gender and age subgroups (?5, 6-10 and ?11 years).
Results: Mean age of children at diagnosis was 8.1±4.1 years. At T1DM onset, the number of children ?5, between 6-10 and ?11 years old was 110 (27.9%), 147 (37.2%) and 138 (34.9%), respectively. The patients were mostly diagnosed at ages 6-8 years (24.1%), followed by cases aged 3-5 years (22.0%). Polyuria and polydipsia were the most common symptoms (94.7%). Mean duration of symptoms was 21.5±18.6 days. Although the patients mostly presented in autumn (30.7%), no season-related significant differences were found. The frequency of ketoacidosis was relatively high (48.5%). When compared to boys, the girls experienced higher rates of ketoacidosis (55.1% vs. 41.7%, p=0.042); had a higher frequency of anti-thyroid peroxidase antibodies (11.7% vs. 4.2%, p=0.049) and higher insulin requirement (0.89±0.41 vs. 0.77±0.36 IU/kg, p=0.005). Cases with a family history of T1DM were more likely to have anti-endomysial antibodies (42.9% vs. 8.1%, p=0.027) and higher initial blood glucose levels (510.5±145.0 vs. 436.1±156.5 mg/dL, p=0.005).
Conclusion: The findings possibly indicate a decreasing age of T1DM onset. The high frequency of ketoacidosis at presentation is noteworthy. Girls had higher rates of ketoacidosis, higher frequency of anti-thyroid antibodies and higher insulin requirements as compared to boys. Patients with a family history of T1DM had higher initial glucose levels and higher frequency of anti-endomysial antibodies.

Keywords: Type 1 diabetes in children,epidemiology of type 1 diabetes mellitus,diabetic ketoacidosis,seasons,autoantibodies,Turkey

Fikri Demir, Hülya Günöz, Nurçin Saka, Feyza Darendeliler, Rüveyde Bundak, Firdevs Baş, Olcay Neyzi. Epidemiologic Features of Type 1 Diabetic Patients between 0 and 18 Years of Age in İstanbul City. J Clin Res Pediatr Endocrinol. 2015; 7(1): 49-56
Manuscript Language: English
LookUs & Online Makale