Objective: The aim of this study is to evaluate the diagnostic accuracy of BIPSS with desmopressin for pediatric CD.
Methods: We included studies performed in children that evaluated the accuracy of BIPSS with desmopressin.
Results: All included studies were case series of children with ACTH-dependent Cushing’s syndrome. The overall accuracy
of BIPSS before stimulation was 84.1% (37/44), and after stimulation it was 92.3% (36/39). The overall lateralizing accuracy
of BIPSS was 50.0 %.
Conclusion: Considering that available evidence is limited, we can state that BIPSS with desmopressin stimulation is
accurate for the diagnosis of pediatric CD, but its lateralizing accuracy is probably not suitable for pediatric clinical practice.