J Clin Res Pediatr Endocrinol. Ahead of Print: JCRPE-68442 | DOI: 10.4274/jcrpe.galenos.2021.2021-12-9

Diagnostic Power of Bilateral Inferior Petrosal Sinus Sampling with Desmopressin in Paediatric Cushing’s Disease

Manuel André Virú-loza¹, Andrea Venegas Quispe^2
1Hospital Nacional Dos de Mayo, Lima, Peru
²ADIECS Association for the Development of Student Research in Health Sciences, Universidad Nacional Mayor de San Marcos

Objective: The aim of this study is to evaluate the diagnostic accuracy of BIPSS with desmopressin for pediatric CD.
Methods: We included studies performed in children that evaluated the accuracy of BIPSS with desmopressin.
Results: All included studies were case series of children with ACTH-dependent Cushing’s syndrome. The overall accuracy
of BIPSS before stimulation was 84.1% (37/44), and after stimulation it was 92.3% (36/39). The overall lateralizing accuracy
of BIPSS was 50.0 %.
Conclusion: Considering that available evidence is limited, we can state that BIPSS with desmopressin stimulation is
accurate for the diagnosis of pediatric CD, but its lateralizing accuracy is probably not suitable for pediatric clinical practice.

Keywords: Petrosal Sinus Sampling, Deamino Arginine Vasopressin, Child, Pituitary ACTH Hypersecretion, Systematic Review

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