ISSN: 1308-5727 | E-ISSN: 1308-5735
Volume: 15 Issue: 4 Year: 2023
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Turkish Society for Pediatric Endocrinology and Diabetes
Cardiac Autonomic Functions in Obese Children [J Clin Res Pediatr Endocrinol]
J Clin Res Pediatr Endocrinol. 2011; 3(2): 60-64 | DOI: 10.4274/jcrpe.v3i2.131

Cardiac Autonomic Functions in Obese Children

Mehmet Emre Taşçılar1, Mehmet Yokuşoğlu2, Mehmet Boyraz1, Oben Baysan2, Cem Köz2, Ruşen Dündaröz3
1Departments Of Pediatrics Division Of Endocrinology, Gulhane Military Medical Academy, Ankara, Turkey
2Departments Of Pediatrics Division Of Cardiology, Gülhane Military Medical Academy, Ankara, Turkey
3Department Of Pediatrics, Bezmialem Vakıf University, İstanbul, Turkey

Objective: The autonomic nervous system is assumed to have a role in the pathophysiology of obesity. In this study, we evaluated the autonomic system by measuring heart rate variability (HRV) in obese children.
Methods: Thirty-two obese and 30 healthy children (mean ages: 11.6±2.0 years and 11.0±2.9 years, respectively) were enrolled in the study. Obesity was defined as a body mass index higher than 97th percentile for age- and gender-specific reference values. All participants were free of any disease and none of them was receiving any medication. Twenty-four-hour ambulatory electrocardiographic recordings were obtained and the time-domain and frequency-domain indices of HRV were analyzed. The study group was evaluated with respect to insulin resistance by HOMA-IR values.
Results: A significant decrease in calculated HRV variables was observed in obese children as compared to controls. The HRV alteration was found in both time-domain and frequency-domain parameters. The subgroup analysis of the study group revealed a significant decrease in all investigated HRV parameters in the insulin-resistant obese children compared to the non-insulin-resistant obese ones.
Conclusions: Our results indicate that HRV is decreased in obese children, which implies parasympathetic withdrawal and sympathetic predominance. A marked decrease in HRV was observed in insulin-resistant obese children compared to their non-insulin-resistant counterparts. We propose that autonomic imbalance pertaining especially to insulin resistance may be involved in the pathogenesis of obesity in pediatric patients

Keywords: Childhood obesity,cardiac autonomic function,heart rate variability,power spectral analysis,time-domain analysis\r\n

Mehmet Emre Taşçılar, Mehmet Yokuşoğlu, Mehmet Boyraz, Oben Baysan, Cem Köz, Ruşen Dündaröz. Cardiac Autonomic Functions in Obese Children. J Clin Res Pediatr Endocrinol. 2011; 3(2): 60-64
Manuscript Language: English
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