ISSN: 1308-5727 | E-ISSN: 1308-5735
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Turkish Society for Pediatric Endocrinology and Diabetes
J Clin Res Pediatr Endocrinol. 2009; 1(3): 105-115 | DOI: 10.4008/jcrpe.v1i3.53
Controversies in the Definition and Treatment of Idiopathic Short Stature (ISS)
Stefania Pedicelli1, Emanuela Peschiaroli1, Emanuela Peschiaroli1, Enrica Violi1, Stefano Cianfarani1‘Rina Balducci’ Center Of Pediatric Endocrinology, Department Of Public Health And Cell Biology, Tor Vergata University, Rome, ItalyThe term idiopathic short stature (ISS) refers to short children with no identifiable disorder of the growth hormone (GH)/insulin like growth factor (IGF) axis and no other endocrine, genetic or organ system disorder. This heterogeneous group of short children without GH deficiency (GHD) includes children with constitutional delay of growth and puberty, familial short stature, or both, as well as those with subtle cartilage and bone dysplasias. In rare cases, ISS is due to IGF molecular abnormalities. In this review we tackle the major challenges in the definition and treatment of ISS.
Keywords: growth,Idiopathic short stature,growth hormone,insulin-like growth factorStefania Pedicelli, Emanuela Peschiaroli, Emanuela Peschiaroli, Enrica Violi, Stefano Cianfarani. Controversies in the Definition and Treatment of Idiopathic Short Stature (ISS). J Clin Res Pediatr Endocrinol. 2009; 1(3): 105-115
Manuscript Language: English
Manuscript Language: English
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