E-ISSN: 2791-8823
Volume: 1 Issue: - Year: 2021
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Turkish Pediatric Endocrinology and Diabetes Society
Urinary NGAL is a Potential Biomarker for Early Renal Injury in Insulin Resistant Obese Non-diabetic Children [J Clin Res Pediatr Endocrinol]
J Clin Res Pediatr Endocrinol. 2021; 13(4): 400-407 | DOI: 10.4274/jcrpe.galenos.2021.2021.0020

Urinary NGAL is a Potential Biomarker for Early Renal Injury in Insulin Resistant Obese Non-diabetic Children

Semra Şen1, Deniz Özalp Kızılay2, Fatma Taneli3, Çınar Özen4, Pelin Ertan4, İpek Özunan4, Raziye Yıldız3, Betül Ersoy2
1Celal Bayar University Faculty of Medicine, Department of Pediatrics, Manisa, Turkey
2Celal Bayar University Faculty of Medicine, Department of Pediatrics, Division of Pediatric Endocrionology, Manisa, Turkey
3Celal Bayar University Faculty of Medicine, Department of Medical Biochemistry, Manisa, Turkey
4Celal Bayar University Faculty of Medicine, Department of Pediatrics, Division of Pediatric Nephrology, Manisa, Turkey

Objective: Neutrophil gelatinase-associated lipocalin (NGAL) is one of the new biomarkers for detecting acute renal injury. There are studies showing the relationship between NGAL and renal injury in obese children. The aim of this study was to investigate whether urinary levels of NGAL, kidney injury molecule-1, and serum cystatin C are increased in insulin resistance (IR) patients before the development of diabetes.
Methods: Cross-sectional, case-controlled study that included non-diabetic obese children and adolescent patients with IR and a nondiabetic obese control group with no IR, who attended a tertiary center pediatric endocrinology outpatient clinic between 2016-2018. Those with diabetes mellitus and/or known renal disease were excluded. NGAL and creatinine (Cr) levels were evaluated in the morning spot urine from all participants. Serum renal function was evaluated.
Results: Thirty-six control and 63 IR patients were included in the study, of whom 68 (68.7%) were girls. The mean age of all participants was 13.12±2.64 years and no statistically significant difference was found between the two groups in terms of age or gender distribution. Median (range) spot urinary NGAL (u-NGAL) values in the IR group were significantly higher at 26.35 (7.01-108.7) ng/mL than in the control group at 19.5 (3.45-88.14) ng/mL (p=0.018). NGAL/Cr ratio was also significantly higher in the IR group compared to the control group (p=0.018).
Conclusion: Obese pediatric patients with IR were shown to have elevated levels of u-NGAL, a marker of renal injury. u-NGAL examination may show early renal injury before development of diabetes.

Keywords: NGAL, renal injury, child, KIM-1, insulin resistance

Semra Şen, Deniz Özalp Kızılay, Fatma Taneli, Çınar Özen, Pelin Ertan, İpek Özunan, Raziye Yıldız, Betül Ersoy. Urinary NGAL is a Potential Biomarker for Early Renal Injury in Insulin Resistant Obese Non-diabetic Children. J Clin Res Pediatr Endocrinol. 2021; 13(4): 400-407
Manuscript Language: English
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