ISSN: 1308-5727 | E-ISSN: 1308-5735
Volume: 16 Issue: 1 Year: 2024

Abstracting & Indexing
Turkish Society for Pediatric Endocrinology and Diabetes
A Rare Cause of Precocious Puberty: Hepatoblastoma [J Clin Res Pediatr Endocrinol]
J Clin Res Pediatr Endocrinol. 2009; 1(6): 281-283 | DOI: 10.4274/jcrpe.v1i6.281

A Rare Cause of Precocious Puberty: Hepatoblastoma

Erdal Eren1, Metin Demirkaya2, Esra D. Papatya Çakır1, Betül Sevinir2, Halil Sağlam1, Ömer Tarım1
1Department Of Pediatric Endocrinology, Uludağ University, Faculty Of Medicine, Bursa, Turkey
2Department Of Pediatric Oncology, Uludağ University, Faculty Of Medicine, Bursa, Turkey

Hepatoblastoma, an embryonal tumor, is one of the most common primary liver tumors in childhood. It secretes human chorionic gonadotropin (hCG), which can cause precocious puberty (PP). Herein, we present a case with PP who had enlarged penile size noticed during a diagnosis of hepatoblastoma. Laboratory examination revealed increased testosterone, alpha-fetoprotein (AFP), and hCG levels. Serum follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels were within prepubertal ranges. The diagnosis of hepatoblastoma was made by liver biopsy. Chemotherapy was administered, and the patient was referred to surgery. Ten months later, testis volumes were below 4 ml bilaterally, and penile length was 5.5 cm. Serum testosterone, AFP, and hCG levels decreased. Resection of the tumor and chemotherapy are essential for the treatment of hepatoblastoma and they can eliminate the symptoms of PP.

Keywords: puberty,hepatoblastoma

Erdal Eren, Metin Demirkaya, Esra D. Papatya Çakır, Betül Sevinir, Halil Sağlam, Ömer Tarım. A Rare Cause of Precocious Puberty: Hepatoblastoma. J Clin Res Pediatr Endocrinol. 2009; 1(6): 281-283
Manuscript Language: English
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