J Clin Res Pediatr Endocrinol. Ahead of Print: JCRPE-74745 | DOI: 10.4274/jcrpe.galenos.2022.2022-2-14

Is There a Predictive Factor for Autoimmune Glanduler Disease Association in Children Diagnosed with Celiac Disease?

Fatma Ýlknur Varol¹, Emine Çamtosun², Mukadder Ayþe Selimoðlu³, Þükrü Güngör^1
1Ýnonu University, Faculty of Medicine, Departments of Pediatric Gastroenterology, Hepatology, and Nutrition, Malatya, Turkey
²Ýnonu University Faculty of Medicine, Department of Pediatric Endocrinology, Malatya, Turkey
³Memorial Atasehir and Bahçelievler Hospitals, Pediatric Gastroenterology. Ýstanbul, Turkey

INTRODUCTION: There is a close relationship between Celiac Disease (CD) and glandular autoimmunity. The aim of this study is to determine the predictive factors for AGD in children with CD.
METHODS: The study included 228 pediatric patients, who were diagnosed with CD between 2010 and 2019. The cases with AGD(Group-1) and those without AGD (Group-2) and the patients with Type1 diabetes mellitus(T1DM) (Group-A) and those without T1DM(Group-B) were retrospectively reviewed and compared in terms of clinical and laboratory features.
RESULTS: AGD was detected in 8.8% (n=20) of the patients [T1DM in 13 (65%), T1DM&Hashimoto thyroiditis (HT) in 3 (15%), HT in 2 (10%), T1DM&Graves' disease (GD) in 1(5%), and GD in 1(5%)]. We observed that T1DM accompanied by HT in three patients andGD in one patient. The mean age at the diagnosis of CD was significantly higher in Group-1(10.93±4.15) compared to Group-2(8.10±4.19)(p<0.05) and also was significantly higher in Group-A compared to Group-B(p<0.05). It was found that the most of the diagnoses of AGD were made before the diagnosis of CD and age was an effective factor. There was no difference between Group-1 and Group-2and Group-Aand Group-B in terms of gender, typical/atypical CD ratio, tissue transglutaminaseA level, HLA-DQ2 and/or HLA-DQ8 positivity rate, and histopathological stage.
DISCUSSION AND CONCLUSION: As a result of this study, it was found that gender, celiac symptoms, TTGA level, HLA type, and histopathological stage had no predictive value for the coexistence of AGD in patients with CD.

Keywords: Autoimmune glandular disease, celiac disease, child, diabetes mellitus type 1, graves disease, hashimoto thyroiditis

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