ISSN: 1308-5727 | E-ISSN: 1308-5735
Volume: 16 Issue: 1 Year: 2024

Abstracting & Indexing
Turkish Society for Pediatric Endocrinology and Diabetes
Effect of Adrenocorticotropic Hormone Stimulation on Ischemia-modified Albumin Levels <i>in vivo</i> [J Clin Res Pediatr Endocrinol]
J Clin Res Pediatr Endocrinol. 2024; 16(1): 84-90 | DOI: 10.4274/jcrpe.galenos.2023.2023-5-22

Effect of Adrenocorticotropic Hormone Stimulation on Ischemia-modified Albumin Levels in vivo

Nursel Muratoğlu Şahin1, Senem Esen1, Şenay Savaş Erdeve1, Salim Neşelioğlu2, Özcan Erel2, Semra Çetinkaya1
1University of Health Sciences Turkey, Dr. Sami Ulus Pediatric Health and Disease and Obstetrics and Gynecology Training and Research Hospital, Clinic of Pediatric Endocrinology, Ankara, Turkey
2Ankara Yıldırım Beyazıt University Faculty of Medicine, Department of Biochemistry, Ankara, Turkey

INTRODUCTION: Ischemia-modified albumin (IMA) formation is associated with increased reactive oxygen species (ROS) production, while increased cortisol leads to decreased ROS levels. We aimed to evaluate the effect of adrenocorticotropic hormone (ACTH) stimulation on IMA levels and whether the effect was dose-dependent or not.
METHODS: A total of 99 subjects with normal ACTH test results were included in the study. Of these, 80 had standard-dose ACTH test while 19 had low-dose ACTH test. Blood samples were collected to determine cortisol and IMA levels; at minutes 0, 30, and 60 following the standard-dose ACTH test and at minutes 0 and 30 following the low-dose ACTH test.
RESULTS: IMA levels decreased significantly within 30 minutes and the decrease continued up to the sixtieth minute (p=0.002) after standard-dose ACTH stimulation. After ACTH stimulation, a weak negative correlation was found between peak cortisol and IMA levels at the thirtieth minute (r=0.233, p=0.02). There was no significant difference in IMA levels after low-dose ACTH stimulation, despite an increase in cortisol (p=0.161).
DISCUSSION AND CONCLUSION: IMA levels decreased rapidly after standard-dose ACTH stimulation, while a decrease in IMA levels was not observed after low-dose ACTH stimulation. The lack of decrease in IMA levels after low-dose ACTH stimulation suggests a possible dose-dependent relationship between ACTH and IMA. The moderate increase in cortisol with no reduction in IMA levels after low-dose ACTH stimulation and the weak correlation between peak cortisol and 30-minute IMA levels after standard-dose ACTH stimulation suggest that ACTH may have a direct effect on IMA.

Keywords: Ischemia-modified albumin, ACTH, cortisol, reactive oxygen species

Nursel Muratoğlu Şahin, Senem Esen, Şenay Savaş Erdeve, Salim Neşelioğlu, Özcan Erel, Semra Çetinkaya. Effect of Adrenocorticotropic Hormone Stimulation on Ischemia-modified Albumin Levels in vivo. J Clin Res Pediatr Endocrinol. 2024; 16(1): 84-90

Corresponding Author: Nursel Muratoğlu Şahin, Türkiye
Manuscript Language: English
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