ISSN: 1308-5727 | E-ISSN: 1308-5735
Volume: 16 Issue: 1 Year: 2024
Forms

Abstracting & Indexing
Turkish Society for Pediatric Endocrinology and Diabetes
Different Aspects of Kidney Function in Well-Controlled Congenital Hypothyroidism [J Clin Res Pediatr Endocrinol]
J Clin Res Pediatr Endocrinol. 2012; 4(4): 193-198 | DOI: 10.4274/Jcrpe.811

Different Aspects of Kidney Function in Well-Controlled Congenital Hypothyroidism

Alaleh Gheissari1, Mahin Hashemipour2, Pooya Khosravi3, Atoosa Adibi4
1Iums, Pediatric Nephrology, Isfahan, Iran, Islamic Republic Of
2Sfahan University Of Medical Sciences, Pediatric Endocrinology, Isfahan, Iran, Islamic Republic Of
3Isfahan University Of Medical Sciences, Pediatrics, Isfahan, Iran, Islamic Republic Of
4Isfahan University Of Medical Sciences, Radiology, Isfahan, Iran, Islamic Republic Of

Objective: Congenital hypothyroidism (CH) increases the prevalence of kidney and urogenital malformations. There are limited studies considering different aspects of kidney function in well-controlled CH patients. We evaluated some features of kidney function in euthyroid children with CH who have been receiving thyroxine hormone since early life.
Methods: This cross-sectional study was conducted in Isfahan, Iran, on 74 children aged 2-15 years old (36 CH patients and 38 healthy children). Inclusion criteria for CH patients were euthyroidism at the time of the survey and initiation of replacement therapy during the early neonatal period. Kidney ultrasound evaluation was performed in all participants. Serum biochemistry included urea, creatinine, sodium (Na), potassium (K), magnesium, calcium, and cystatin C levels. Urine electrolytes, fraction excretion (FE) of electrolytes and microalbumin, and glomerular filtration rate (GFR) were also determined.
Results: The male/female ratio was 0.8/1 and 1.5/1 in the patient and control groups, respectively. Mean age and height did not differ significantly between the two groups. Ultrasound evaluation of the kidney revealed that the anteroposterior diameter of the right kidney was significantly higher in CH patients as compared to healthy subjects. No significant difference was observed between GFRs in patients with CH and healthy children. The mean values for FENa and FEK were significantly higher in the patient group.
Conclusions: Increased FENa and FEK may be a manifestation of impaired tubular maturation in CH. More longitudinal studies are needed to evaluate kidney function in CH patients.

Keywords: congenital hypothyroidism,kidney function,kidney size

Alaleh Gheissari, Mahin Hashemipour, Pooya Khosravi, Atoosa Adibi. Different Aspects of Kidney Function in Well-Controlled Congenital Hypothyroidism. J Clin Res Pediatr Endocrinol. 2012; 4(4): 193-198
Manuscript Language: English
LookUs & Online Makale