ISSN: 1308-5727 | E-ISSN: 1308-5735
Volume: 16 Issue: 1 Year: 2024

Abstracting & Indexing
Turkish Society for Pediatric Endocrinology and Diabetes
Sepsis-induced Pancytopenia in an Adolescent Girl with Thyroid Storm: A Case Report [J Clin Res Pediatr Endocrinol]
J Clin Res Pediatr Endocrinol. Ahead of Print: JCRPE-86158 | DOI: 10.4274/jcrpe.galenos.2023.2022-10-3

Sepsis-induced Pancytopenia in an Adolescent Girl with Thyroid Storm: A Case Report

Qing Zhou1, Li-Yong Zhang2, Qing-Xian Fu3, Chao-Chun Zou4, Hui Liu3
1Department of Endocrinology, Fujian Maternity and Child Health Hospital, Fuzhou, China
2Department of Thyroid and Vascular Surgery, Minimal Invasive Center, Fujian Medical University Union Hospital, Fuzhou, China
3Department of Endocrinology, Fujian Children's Hospital, Fuzhou, China
4Department of Endocrinology, Children’s Hospital of Zhejiang University School of Medicine. Hangzhou, China

Thyroid storm is a rare but life-threatening condition mainly triggered by infection and abrupt discontinuation of antithyroid drug therapy for Graves’ disease. Pancytopenia is a rare adverse reaction to antithyroid drugs. We present a 13-year-old girl with thyroid storm and pancytopenia with symptoms similar to those of methimazole-induced pancytopenia. Although in this context the use of methimazole is still under debate, due to multiple normal complete blood counts monitored during fever, sepsis-induced pancytopenia with thyroid storm was considered, and methimazole treatment combined with methylprednisolone and meropenem was able to resolve both pancytopenia and thyroid storm. During the period of infection and antithyroid drug therapy, close monitoring of complete blood count may help differentiate the aetiology of pancytopenia. This is the first paediatric case report that outlines the use of methimazole in the management of thyroid storm with pancytopenia.

Keywords: Thyroid Storm, Pancytopenia, Sepsis; Antithyroid Drug

Corresponding Author: Hui Liu, China
Manuscript Language: English
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