ISSN: 1308-5727 | E-ISSN: 1308-5735
Volume: 16 Issue: 1 Year: 2024
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Turkish Society for Pediatric Endocrinology and Diabetes
Constitutional Growth Delay Pattern of Growth in Velo-Cardio-Facial Syndrome: Longitudinal follow up and final height of two cases [J Clin Res Pediatr Endocrinol]
J Clin Res Pediatr Endocrinol. 2008; 1(1): 43-48 | DOI: 10.4008/jcrpe.v1i1.13

Constitutional Growth Delay Pattern of Growth in Velo-Cardio-Facial Syndrome: Longitudinal follow up and final height of two cases

Serap Turan1, Nihal Özdemir1, Tülay Güran1, Figen Akalın2, Teoman Akçay1, Canan Ayabakan2, Yüksel Yılmaz3, Abdullah Bereket1
1Marmara University, Department of Pediatric Endocrinology, Istanbul, Turkey
2Marmara University, Department of Cardiology, Istanbul, Turkey
3Marmara University, Department of Neurology, Istanbul, Turkey

We report two patients with velo-cardio-facial syndrome (VCFS) who were admitted to our pediatric endocrinology clinic because of short stature and followed longitudinally until attainment of final height. Both patients followed a growth pattern consistent with constitutional delay of puberty with normal and near normal final height. Case 2 also had partial growth hormone (GH) deficiency and severe short stature (height SDS -3.4 SDS), but showed spontaneous catch-up and ended up with a final height of -2 SDS. These cases suggest that short stature in children with VCFS is due to a pattern of growth similar to that observed in constitutional delay of growth and puberty.

Keywords: Velo-cardio-facial syndrome, 22q11.2, growth, short stature, growth hormone deficiency, normal genotype

Serap Turan, Nihal Özdemir, Tülay Güran, Figen Akalın, Teoman Akçay, Canan Ayabakan, Yüksel Yılmaz, Abdullah Bereket. Constitutional Growth Delay Pattern of Growth in Velo-Cardio-Facial Syndrome: Longitudinal follow up and final height of two cases. J Clin Res Pediatr Endocrinol. 2008; 1(1): 43-48

Corresponding Author: Serap Turan
Manuscript Language: English
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