Serum IGF-1 and IGFBP-3 Levels in Healthy Children Between 0 and 6 Years of Age
Bilgin Yüksel1, M. Nuri Özbek2, Neslihan Önenli Mungan1, Feyza Darendeliler3, Bahar Budan3, Aysun Bideci4, Ergün Çetinkaya5, Merih Berberoğlu6, Olcay Evliyaoğlu7, Ediz Yeşilkaya8, İlknur Arslanoğlu9, Şükran Darcan10, Ruveyda Bundak3, Olcay Ercan111Cukurova University, Faculty Of Medicine, Pediatric Endocrinology And Metabolism, Adana, Turkey2Diyarbakir Children'S Hospital, Pediatric Endocrinology, Diyarbakir, Turkey
3Istanbul University, Faculty Of Medicine, Pediatric Endocrinology, Istanbul, Turkey
4Gazi University, Faculty Of Medicine, Pediatric Endocrinology, Ankara, Turkey
5Diskapi Hospital, Pediatric Endocrinology, Ankara, Turkey
6Ankara University, Faculty Of Medicine, Pediatric Endocrinology, Ankara, Turkey
7Kirikkale University, Faculty Of Medicine, Pediatric Endocrinology, Kirikkale, Turkey
8Kirikkale Gata Hospital, Pediatric Endocrinology, Ankara, Turkey
9Duzce University, Faculty Of Medicine, Pediatric Endocrinology, Duzce, Turkey
10Ege University, Faculty Of Medicine, Pediatric Endocrinology And Metabolism, Izmir, Turkey
11Istanbul University, Cerrahpasa Medical Faculty, Pediatric Endocrinology, Istanbul, Turkey
Objective: Along with growth hormone (GH) levels, measurements of serum insulin-like growth factor-1 (IGF-1) and IGF-binding protein-3 (IGFBP-3) are used in the diagnosis of GH deficiency and in monitoring the efficacy and safety of long-term GH treatment. The purpose of the present study was to establish reference values for serum IGF-1 and IGFBP-3 in healthy Turkish children less than 6 years of age.
Methods: This study was designed as a multicenter project. Five hundred sixty-seven healthy children younger than 6 years of age from different geographical regions of Turkey, with weight and height values between the 10th and 90th percentiles according to the national standards were included in the study. In addition to anthropometric parameters, serum IGF-1 and IGFBP-3 levels were measured in all subjects.
Results: Although not statistically significant, the serum IGF-1 levels in infants at age 6 months were lower than those in infants at age 3 months. The IGF-1 levels showed a slow increase with age. Serum IGF-1 levels were lower in girls as compared to boys only at age 6 months. No correlation was found between either serum IGFBP-3 levels and body mass index (BMI) or serum IGFBP-3 and weight and height standard deviation scores (SDS). A weak correlation was observed between serum IGF-1 and IGFBP-3 concentrations.
Conclusions: The age- and gender-specific reference values for serum IGF-1 and IGFBP-3 reported in this study will aid in the diagnosis of GH deficiency and in the monitoring of children receiving GH treatment.
Manuscript Language: English
