ISSN: 1308-5727 | E-ISSN: 1308-5735
Volume: 16 Issue: 1 Year: 2024
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Turkish Society for Pediatric Endocrinology and Diabetes
Adding Multiple Adipokines into the Model do not Improve Weight Gain Prediction by Leptin Levels in Newborns [J Clin Res Pediatr Endocrinol]
J Clin Res Pediatr Endocrinol. 2016; 8(3): 321-324 | DOI: 10.4274/jcrpe.2693

Adding Multiple Adipokines into the Model do not Improve Weight Gain Prediction by Leptin Levels in Newborns

Consuelo Treviño-Garza1, Cynthia M. Estrada-Zúñiga1, Leonardo Mancillas-Adame2, Laura Villarreal-Martínez1, Jesús Z. Villarreal-Pérez2, Isaías Rodríguez-Balderrama1, Fernando F. Montes-Tapia1, Manuel E. de la O. Cavazos1
1University Autonomous Of Nuevo Leon, ‘Dr. José E. González’ University Hospital, Department Of Pediatrics, Monterrey/Nuevo Leon, Mexico
2University Autonomous Of Nuevo Leon, ‘Dr. José E. González’ University Hospital, Division Of Endocrinology, Monterrey/Nuevo Leon, Mexico

Objective: Most adipose tissue programming is realized in early life. Also, the postnatal three months, rather than the later phases of infancy, may be more relevant in the development of an adverse cardiometabolic risk profile. The adipokines phenotype, as a predictor of early-life weight gain, has been recently explored in cord blood. To determine whether in addition to leptin levels in cord samples, adiponectin, interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), resistin, plasminogen activator inhibitor-1 (PAI-1), and tumor necrosis factor alpha (TNF-?) levels improve weight gain prediction during the first three months of life.
Methods: Adiponectin, IL-6, MCP-1, leptin, resistin, PAI-1, and TNF-? were measured by multiplex immunoassay in a subsample of 86 healthy term newborns.
Results: Leptin levels significantly predicted weight gain at 3 months of follow-up (r2=0.09, p=0.006). In the multivariate analysis, including additional adipokines in the model, stepwise or all at once, did not increase the prediction of weight gain after the first three months of life.
Conclusion: Adding adiponectin, IL-6, MCP-1, resistin, PAI-1, and TNF-? to the prediction model of weight gain in healthy newborns did not prove to be useful. It is probable that their relative contribution to weight gain is not important. Only leptin was relevant as a predictor of weight gain at the 3-month endpoint.

Keywords: leptin,Adipokines,prediction,weight gain,newborn

Consuelo Treviño-Garza, Cynthia M. Estrada-Zúñiga, Leonardo Mancillas-Adame, Laura Villarreal-Martínez, Jesús Z. Villarreal-Pérez, Isaías Rodríguez-Balderrama, Fernando F. Montes-Tapia, Manuel E. de la O. Cavazos. Adding Multiple Adipokines into the Model do not Improve Weight Gain Prediction by Leptin Levels in Newborns. J Clin Res Pediatr Endocrinol. 2016; 8(3): 321-324
Manuscript Language: English
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