ISSN: 1308-5727 | E-ISSN: 1308-5735
Volume: 14 Issue: 2 Year: 2022
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Turkish Society for Pediatric Endocrinology and Diabetes
FGF21 Levels and Bone Mineral Density in Metabolically Healthy and Metabolically Unhealthy Obese Children [J Clin Res Pediatr Endocrinol]
J Clin Res Pediatr Endocrinol. Ahead of Print: JCRPE-93446 | DOI: 10.4274/jcrpe.galenos.2022.2022-1-15

FGF21 Levels and Bone Mineral Density in Metabolically Healthy and Metabolically Unhealthy Obese Children

Filiz Akduman1, Zeynep Şıklar2, Elif Özsu2, Özlem Doğan3, Metin Kemal Kır4, Merih Berberoğlu2
1Department of Pediatrics, Ankara University School of Medicine, Ankara, Turkey
2Department of Pediatric Endocrinology, Ankara University School of Medicine, Ankara, Turkey
3Department of Clinical Biochemistry, Ankara University School of Medicine, Ankara, Turkey
4Department of Nuclear Medicine, Ankara University School of Medicine, Ankara, Turkey

INTRODUCTION: The harmful or beneficial effect of obesity on bone mineral density (BMD) remains controversial in children and adolescence. Fibroblast growth factor 21 (FGF21) is a metabolic factor that plays a specific role in the regulation of carbohydrate and lipid metabolism. However, the role of FGF-21 in bone metabolism seems paradoxical and complex.
Objective: It was aimed to determine whether serum FGF21 level is associated with BMD in obese children and adolescents.
METHODS: The study was conducted with the participation of children and adolescents aged 8-18 years. 98 children were included in the study group and 44 children were included in the control group. BMD, in addition to the routine obesity workup, which includes fasting blood glucose, fasting insulin levels, lipid profile, and liver enzymes; serum FGF21 levels have been analyzed.
RESULTS: The mean age of the obese group was 13.34 ± 2.24 years and the mean age of the control group was 13.48 ± 2.87 years. According to the International Diabetes Federation criteria, 15 of 98 (15.3%) patients are MS (metabolically unhealthy). FGF-21 levels were 193,54±139,62 mg/dl in the obese group and 158,69±151,81 mg/dl in the control group (p=0.06). There was no difference between the FGF-21 and BMD z-score values of girls and boys in the obese and control groups (p>0.05).
DISCUSSION AND CONCLUSION: BMD-z score increases in obese children compared to the control group. It is observed that BMD-z score increases more when metabolic risk factors accompany it. There was no significant relationship between FGF21 levels and BMD z-score values in obese children.

Keywords: Obesity, children, bone mineral density, FGF21



Corresponding Author: Filiz Akduman, Türkiye
Manuscript Language: English
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