ISSN: 1308-5727 | E-ISSN: 1308-5735
Volume: 16 Issue: 1 Year: 2024
Forms

Abstracting & Indexing
Turkish Society for Pediatric Endocrinology and Diabetes
Prevalence and Related Factors of Euthyroid Sick Syndrome in Children with Untreated Cancer According to Two Different Criteria [J Clin Res Pediatr Endocrinol]
J Clin Res Pediatr Endocrinol. 2018; 10(3): 198-205 | DOI: 10.4274/jcrpe.0015

Prevalence and Related Factors of Euthyroid Sick Syndrome in Children with Untreated Cancer According to Two Different Criteria

Ali Duyu1, Elvan Çağlar Çıtak1, Erdem Ak1, Serhan Kupeli2, Begül Yağcı Küpeli3, İbrahim Bayram2, Gülay Sezgin2, Gülçin Eskendari4, Kerem Sezer5
1Mersin University Faculty of Medicine, Department of Pediatric Oncology, Mersin, Turkey
2Çukurova University Faculty of Medicine, Department of Pediatric Oncology, Adana, Turkey
3Adana City Training and Research Hospital, Clinic of Pediatric Oncology, Adana, Turkey
4Mersin University Faculty of Medicine, Department of Medical Biochemistry, Mersin, Turkey
5Mersin University Faculty of Medicine, Department of Internal Medicine, Division of Endocrinology and Metabolism, Mersin, Turkey

Objective: In this study, we evaluated the frequency of euthyroid sick syndrome (ESS) among patients with childhood cancer and its association with the stage of disease, nutritional parameters and cytokines levels.
Methods: Eighty newly diagnosed children were included in the study. ESS was assessed in two different ways. According to criteria 1 ESS was present if free triiodothyronine (fT3) was below the lower limit and free thyroxine was within the normal or low limits, thyroid-stimulating hormone (TSH) was in the normal range. According to criteria 2, in addition to the above, it was required that reverse triiodothyronine (rT3) be performed and was higher than normal limits.
Results: Three of our pediatric patients had subclinical hypothyroidism and two had subclinical hyperthyroidism. Out of 75 patients, ESS was identified in 14 (17.3%) according to criteria 1 and in eight (10.6%) according to criteria 2. Only fT3 levels were significantly different in the ESS (+) and ESS (-) groups (p<0.05) according to criteria 1. A significantly negative correlation between interleukin (IL)-6 and fT3 was found, according to both sets of criteria. tumor necrosis factor alpha was negatively correlated with fT3 levels only in the criteria 1 group. There were no correlations between IL-1ß and fT3, free thyroxine, rT3 and TSH levels.
Conclusion: ESS may occur in childhood cancer and thyroid function testing should be performed routinely when cancer is diagnosed.

Keywords: Euthyroid sick syndrome, children, cancer, interleukin 6, interleukin 8, tumor necrosis factor alpha

Ali Duyu, Elvan Çağlar Çıtak, Erdem Ak, Serhan Kupeli, Begül Yağcı Küpeli, İbrahim Bayram, Gülay Sezgin, Gülçin Eskendari, Kerem Sezer. Prevalence and Related Factors of Euthyroid Sick Syndrome in Children with Untreated Cancer According to Two Different Criteria. J Clin Res Pediatr Endocrinol. 2018; 10(3): 198-205
Manuscript Language: English
LookUs & Online Makale