ISSN: 1308-5727 | E-ISSN: 1308-5735
Volume: 14 Issue: 2 Year: 2022

Abstracting & Indexing
Turkish Society for Pediatric Endocrinology and Diabetes
An Evaluation of Glucose Metabolism and Cardiovascular Risk Factors in Prepubertal Girls with Premature Pubarche [J Clin Res Pediatr Endocrinol]
J Clin Res Pediatr Endocrinol. Ahead of Print: JCRPE-98704 | DOI: 10.4274/jcrpe.galenos.2022.2022-1-1

An Evaluation of Glucose Metabolism and Cardiovascular Risk Factors in Prepubertal Girls with Premature Pubarche

Digdem Bezen1, Filiz Tutunculer Kokenli2, Emine Dilek2, Didem Ag Seleci3, Hakan Erbas3
1Department of Pediatrics, Pediatric Endocrinology, University of Health Sciences, Prof. Dr. Cemil Taşçıoğlu City Hospital, İstanbul, Turkey
2Department of Pediatrics, Pediatric Endocrinology, Trakya University, Medical Faculty, Edirne, Turkey
3Department of Biochemistry, Trakya University, Medical Faculty, Edirne, Turkey

INTRODUCTION: Objective: Premature pubarche (PP) is a risk factor for metabolic syndrome (MS). We aimed to evaluate if glucose-insulin metabolism, cardiovascular risk factors, cardiovascular risk factors in family (FCVRF) create a risk for insulin resistance and if PP is a risk factor alone for metabolic syndrome (MS) in normal weight prepubertal girls with PP.
METHODS: Methods: Prepubertal, non-obese 35 PP girls with normal birth weight and 35 control girls were evaluated for FCVRF, anthropometric measurements, blood pressure, lipid profile, fasting blood glucose-insulin, hemoglobin A1c (HbA1c), sex hormone binding globulin (SHBG), leptin, adiponectin, tumor necrotizing factor-alpha (TNF-α), androgen levels, bone age. Oral glucose tolerance test was performed in PP participants. homeostasis model of assessment of insulin resistance (HOMA-IR), fasting glucose/insulin ratio, atherogenic index (AI), free androgen index (FAI) were calculated. PP participants were, also, divided into two subgroups by presence of FCVRF.
RESULTS: Results: HbA1c, lipid profile, testosterone, leptin, adiponectin, TNF-α, HOMA-IR, glucose/insulin ratio, AI, fasting glucose-insulin levels were similar. In PP group FAI was significantly higher (p=0.001), whereas SHBG was significantly lower (p=0.010) than the control group. Leptin levels of FCVRF+ and FCVRF- subgroups were 15.2±9.1 and 9.7±7.2 ng/ml, respectively (p=0.016).
DISCUSSION AND CONCLUSION: Conclusion: As PP is not a risk factor alone for impaired glucose metabolism and insulin resistance in prepubertal non-obese girls with normal birth weight, it is unnecessary to examine in detail such cases before puberty. Low SHBG levels in PP group and high leptin levels in FCVRF+ subgroup might suggest that these may be predictive for MS in the future.

Keywords: premature pubarche, prepubertal, leptin, glucose metabolism, adipocytokines, cardiovascular risk

Corresponding Author: Digdem Bezen, Türkiye
Manuscript Language: English
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