ISSN: 1308-5727 | E-ISSN: 1308-5735
Volume : 7 Issue : 1 Year : 2024
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Turkish Society for Pediatric Endocrinology and Diabetes
ß-3AR W64R Polymorphism and 30-Minute Post-Challenge Plasma Glucose Levels in Obese Children [J Clin Res Pediatr Endocrinol]
J Clin Res Pediatr Endocrinol. 2015; 7(1): 7-12 | DOI: 10.4274/jcrpe.1629

ß-3AR W64R Polymorphism and 30-Minute Post-Challenge Plasma Glucose Levels in Obese Children

Hasibe Verdi1, Sibel Tulgar Kınık2, Yaprak Yılmaz Yalçın1, Nursel Muratoğlu Şahin2, Ayşe Canan Yazıcı3, F. Belgin Ataç1
1Başkent University Faculty Of Medicine, Department Of Medical Biology, Ankara, Turkey
2Başkent University Faculty Of Medicine, Department Of Pediatric Endocrinology, Ankara, Turkey
3Başkent University Faculty Of Medicine, Department Of Biostatistics, Ankara, Turkey

Objective: In this study, we aimed to investigate the association of W64R polymorphism of the ß3-adrenergic receptor gene (ß-3AR) with childhood obesity and related pathologies.
Methods: ß-3AR gene W64R genotyping was carried out in 251 children aged 6-18 years. Of these subjects, 130 were obese (62 boys) and 121 were normal-weight (53 boys). In the obese group, fasting lipids, glucose and insulin levels were measured. Oral glucose tolerance test (OGTT) was performed in 75 of the obese patients.
Results: The frequency of W64R genotype was similar in obese and non-obese children. In obese children, relative body mass index, waist-to-hip ratio, serum lipid, glucose and insulin levels, as well as homeostasis model assessment of insulin resistance (HOMA-IR) scores were not different between Arg allele carriers (W64R and R64R) and noncarriers (W64W). In 75 obese children, OGTT results showed that Arg allele carriers had significantly higher 30-minute glucose levels (p=0.027).
Conclusion: W64R polymorphism of the ß-3AR gene is not associated with obesity and waist-to-hip ratio in Turkish children. Although there were no relationships between the genotypes and lipid, glucose/insulin levels or HOMA-IR, the presence of W64R variant seemed to have an unfavorable influence on early glucose excursion after glucose loading.

Keywords: obesity,children,ß3-adrenergic receptor gene polymorphism,oral glucose tolerance test

Hasibe Verdi, Sibel Tulgar Kınık, Yaprak Yılmaz Yalçın, Nursel Muratoğlu Şahin, Ayşe Canan Yazıcı, F. Belgin Ataç. ß-3AR W64R Polymorphism and 30-Minute Post-Challenge Plasma Glucose Levels in Obese Children. J Clin Res Pediatr Endocrinol. 2015; 7(1): 7-12
Manuscript Language: English
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