E-ISSN: 2791-8823
Volume : 14 Issue : 1 Year : 2022
Forms

Abstracting & Indexing
Turkish Society for Pediatric Endocrinology and Diabetes
Silent Corticotroph Tumor with Adrenocortical Choristoma in an Eleven-year-old Boy [J Clin Res Pediatr Endocrinol]
J Clin Res Pediatr Endocrinol. 2022; 14(1): 126-130 | DOI: 10.4274/jcrpe.galenos.2021.2020.0258

Silent Corticotroph Tumor with Adrenocortical Choristoma in an Eleven-year-old Boy

Hande Turan1, Gürkan Tarçın1, Özgür Mete2, Ada Bulut Sinoplu3, Saadet Olcay Evliyaoğlu1, Büge Öz4, Oya Ercan1
1University of Health Sciences Turkey, İstanbul University-Cerrahpaşa, Cerrahpaşa Faculty of Medicine, Department of Pediatric Endocrinology, İstanbul, Turkey
2University of Toronto, Department of Laboratory Medicine and Pathobiology, Toronto, Canada; University Health Network, Department of Pathology, Toronto, Canada
3University of Health Sciences Turkey, İstanbul University-Cerrahpaşa, Cerrahpaşa Faculty of Medicine, Department of Pediatrics, İstanbul, Turkey
4University of Health Sciences Turkey, İstanbul University-Cerrahpaşa, Cerrahpaşa Faculty of Medicine, Department of Pathology, İstanbul, Turkey

Silent corticotroph tumors are composed of corticotroph cells, but do not manifest any biochemical or clinical evidence of hypercortisolism. A choristoma is a benign, congenital proliferation of histologically mature tissue elements normally not present at the site of occurrence. The existence of adrenocortical cells within the pituitary gland, which can be explained as a choristoma, is a very rare entity, and the co-occurrence of these two entities have only been reported in few cases. We report an 11-year-old boy with central hypothyroidism. On cranial magnetic resonance imaging a pituitary tumor was detected, and histopathological studies led to a diagnosis of an adrenal choristoma and a silent corticotroph tumor in the pituitary gland. The presence of adrenocortical cells were confirmed by positive calretinin, inhibin and Melan A staining, and the corticotroph cells by immunohistochemistry demonstrating adrenocorticotropic hormone positivity. Herein, we report the fourth and the youngest case of silent corticotroph tumor with adrenocortical choristoma in the literature. Even though the underlying mechanism is not fully understood, suggested mechanisms are discussed.

Keywords: Adrenocortical choristoma, corticotroph adenoma, steroidogenic factor 1

Hande Turan, Gürkan Tarçın, Özgür Mete, Ada Bulut Sinoplu, Saadet Olcay Evliyaoğlu, Büge Öz, Oya Ercan. Silent Corticotroph Tumor with Adrenocortical Choristoma in an Eleven-year-old Boy. J Clin Res Pediatr Endocrinol. 2022; 14(1): 126-130

Corresponding Author: Hande Turan, Türkiye
Manuscript Language: English
LookUs & Online Makale