High-Sensitivity C-Reactive Protein Levels and ?Metabolic Disorders in Obese and Overweight ?Children and Adolescents
Konstantinos Kitsios1, Maria Papadopoulou2, Konstantina Kosta2, Nikolaos Kadoglou3, Maria Papagianni2, Kiriaki Tsiroukidou21G.Gennimatas” General Hospital, Department of Internal Medicine, Thessaloniki, Greece2Aristotle University of Thessaloniki, Hippokration General Hospital, Third Department of Pediatrics, Thessaloniki, Greece
3Foundation of Biomedical Research, Academy of Athens, Athens, Greece
Objective: To evaluate the contribution of cytotoxic T-Iymphocyte antigen-4 (CTLA-4)+49A/G polymorphism to the susceptibility to type-1 diabetes (T1D) in Turkish children.
Methods: A case-control study was designed to include 91 Turkish children with T1D and 99 healthy controls. CTLA-4 (+99A/G) gene polymorphism typing was done by PCR amplification followed by restriction fragment length polymorphism method.
Results: The genotype and allele frequencies of the CTLA-4 (+99A/G) polymorphism in patients with T1D were not different from those in the controls (p>0.05). The allele frequency of G was 36.2% in patients with T1D, and 31.8% in controls (p>0.05). Additionally, this polymorphism was not associated with the clinical and laboratory characteristics of the patients with T1D (p>0.05).
Conclusions: Our case-control study suggests that the CTLA-4 (+99A/G) gene polymorphism is not associated with T1D in the Turkish population.
Manuscript Language: English
