ISSN: 1308-5727 | E-ISSN: 1308-5735
Volume : Issue : Year : 2024
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Turkish Society for Pediatric Endocrinology and Diabetes
Elemental Milk Formula as a Possible Cause of Hypophosphatemic Rickets in Wiedemann-Steiner Syndrome [J Clin Res Pediatr Endocrinol]
J Clin Res Pediatr Endocrinol. Ahead of Print: JCRPE-14632 | DOI: 10.4274/jcrpe.galenos.2022.2022-8-23

Elemental Milk Formula as a Possible Cause of Hypophosphatemic Rickets in Wiedemann-Steiner Syndrome

Fahad Al Juraibah1, Maali Melha1, Azam Alromaih2, Areej Al-sunaid4, Hamad Abdullah Alkhalaf4
1Pediatric Department, King Abdullah Specialist Children’s Hospital, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia
2College of Medicine, King Saud bin Abdul-Aziz University for Health Sciences, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia
3King Abdullah International Medical Research Center, Ministry of National Guard Health Affairs Riyadh, Saudi Arabia
4Pediatric Department, King Abdullah Specialist Children’s Hospital, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia and College of Medicine, King Saud bin Abdul-Aziz University for Health Sciences, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia and King Abdullah International Medical Research Center, Ministry of National Guard Health Affairs Riyadh, Saudi Arabia

Phosphate has a fundamental role in bone mineralization, and its chronic deficiency has multiple negative consequences in the body including defects in bone mineralization that will manifest in children as rickets and osteomalacia. We present here a young boy known to have Wiedemann–Steiner Syndrome with multiple co-morbidities that necessitated gastric tube feeding. The child at 22 months was found to have hypophosphatemia and a high alkaline phosphatase level associated with rachitic skeletal manifestations that were attributed to low phosphate intake and/or gastrointestinal absorption as there was no evidence of excessive phosphate wasting based on appropriate tubular renal reabsorption of phosphate. The primary nutritional source was an elemental amino acid-based milk formula (Neocate®) from 12 months of age. After switching from Neocate® to another elemental amino-acid based milk formula, all biochemical and radiological abnormalities returned to normal, indicating that the Neocate® formula was the possible cause of the patient’s low phosphate intake. However, in the literature, this formula-associated effect was only described in a limited number of patients. Whether or not some patient-related factors, such as the very rare syndrome described in our patient, could influence this effect warrants further exploration.

Keywords: Phosphopenic rickets, osteomalacia, neocate



Corresponding Author: Fahad Al Juraibah, Saudi Arabia
Manuscript Language: English
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