ISSN: 1308-5727 | E-ISSN: 1308-5735
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Turkish Society for Pediatric Endocrinology and Diabetes
High Prenatal Exposure to Bisphenol A Reduces Anogenital Distance in Healthy Male Newborns [J Clin Res Pediatr Endocrinol]
J Clin Res Pediatr Endocrinol. 2018; 10(1): 25-29 | DOI: 10.4274/jcrpe.4817

High Prenatal Exposure to Bisphenol A Reduces Anogenital Distance in Healthy Male Newborns

Emil Mammadov1, Murat Uncu2, Ceyhun Dalkan3
1Near East University Faculty of Medicine, Department of Pediatric Surgery, Nicosia, Cyprus
2Near East University Faculty of Medicine, Department of Biochemistry, Nicosia, Cyprus
3Near East University Faculty of Medicine, Department of Pediatrics, Nicosia, Cyprus

Objective: To estimate the relationship between cord blood bisphenol A (BPA) levels and anogenital measurements in healthy newborns.
Methods: Pregnancy and birth history, together with body mass and length data, anogenital measurements, penile measurements and cord blood samples were obtained from healthy newborns. Cord blood concentration of BPA was analyzed by sandwich enzyme-linked immunosorbent assays kit.
Results: Among 130 healthy newborns (72 boys, 58 girls), mean anopenile distance was 45.2±6 mm and anoscrotal distance was 21.9±5.4 mm in boys; mean anoclitoral distance was 33.8±6.6 mm and mean anofourchette distance was 12.2±4.9 mm in girls. Mean cord blood BPA level was 4.75±2.18 ng/mL. 90th percentile value for cord blood BPA was 8.26 ng/mL and the analysis showed a statistically significant correlation between anoscrotal distance and cord blood BPA levels above the 90th percentile (p=0.047) in boys. The changes in anogenital distance in girls were not statistically significant.
Conclusion: We showed a significant association between high cord blood BPA levels and shortened anoscrotal distance in male newborns. However, this result should be interpreted with caution since there were no significant external genital abnormalities in our study group.

Keywords: Anogenital distance,bisphenol A,cord blood,newborn

Emil Mammadov, Murat Uncu, Ceyhun Dalkan. High Prenatal Exposure to Bisphenol A Reduces Anogenital Distance in Healthy Male Newborns. J Clin Res Pediatr Endocrinol. 2018; 10(1): 25-29
Manuscript Language: English
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