ISSN: 1308-5727 | E-ISSN: 1308-5735
Volume : 9 Issue : 1 Year : 2024
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Turkish Society for Pediatric Endocrinology and Diabetes
Subclinical Hypothyroidism in Danish Lean and Obese Children and Adolescents [J Clin Res Pediatr Endocrinol]
J Clin Res Pediatr Endocrinol. 2017; 9(1): 8-16 | DOI: 10.4274/jcrpe.3319

Subclinical Hypothyroidism in Danish Lean and Obese Children and Adolescents

Maria Dahl1, Johanne Dam Ohrt1, Cilius Esmann Fonvig2, Julie Tonsgaard Kloppenborg3, Oluf Pedersen2, Torben Hansen4, Jens-Christian Holm1
1Copenhagen University Hospital Holbæk, The Children’S Obesity Clinic, Department Of Pediatrics, Holbæk, Denmark
2University Of Copenhagen Faculty Of Health And Medical Science, The Novo Nordisk Foundation Center For Basic Metabolic Research, Section Of Metabolic Genetics, Copenhagen, Denmark
3University Of Copenhagen, Herlev Hospital, Department Of Pediatrics, Herlev, Denmark
4University Of Southern Denmark, The Faculty Of Health Sciences, Odense, Denmark

Objective: Thyroid abnormalities are common in obese children. The aim of the present study was to examine the prevalence of subclinical hypothyroidism (SH) and to determine how circulating thyroid hormone concentrations correlate with anthropometrics in Danish lean and obese children and adolescents.
Methods: In this cross-sectional study, we included 3006 children and adolescents, aged 6-18 years, from the Registry of the Danish Childhood Obesity Biobank. The overweight/obese group (n=1796) consisted of study participants with a body mass index (BMI) standard deviation score (SDS) ?1.28. The control group (n=1210) comprised lean children with a BMI SDS <1.28. All participants were characterized by anthropometrics (weight, height, and waist circumference) and fasting serum concentrations of thyroid-stimulating hormone (TSH), free triiodothyronine, and free thyroxine (fT4) at baseline.
Results: The prevalence of SH was higher among overweight/obese compared to lean study participants (10.4% vs. 6.4%, p=0.0001). In the overweight/obese group, fasting serum TSH concentrations were associated positively with BMI SDS (p<0.0001) and waist-height ratio (WHtR) (p<0.0001) independent of age, sex, and pubertal developmental stage, whereas fasting serum fT4 concentrations were associated positively only with WHtR. The odds ratio of exhibiting SH was 1.8 when being overweight/obese compared with lean (p=0.0007) and 1.8 when presenting with a WHtR >0.5 (p=0.0003).
Conclusion: The prevalence of SH was higher among overweight/obese study participants. The positive correlations of circulating TSH and fT4 with WHtR suggest that central obesity, independent of the overall degree of obesity, augments the risk of concurrent thyroid abnormalities in children and adolescents with obesity.

Keywords: Childhood obesity, thyroid hormones, waist-height ratio

Maria Dahl, Johanne Dam Ohrt, Cilius Esmann Fonvig, Julie Tonsgaard Kloppenborg, Oluf Pedersen, Torben Hansen, Jens-Christian Holm. Subclinical Hypothyroidism in Danish Lean and Obese Children and Adolescents. J Clin Res Pediatr Endocrinol. 2017; 9(1): 8-16
Manuscript Language: English
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