ISSN: 1308-5727 | E-ISSN: 1308-5735
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Turkish Society for Pediatric Endocrinology and Diabetes
Thyroid Function in Small for Gestational Age Newborns: A Review [J Clin Res Pediatr Endocrinol]
J Clin Res Pediatr Endocrinol. 2013; 5(1): 2-7 | DOI: 10.4274/Jcrpe.846

Thyroid Function in Small for Gestational Age Newborns: A Review

Franco Bagnoli1, Farmeschi Laura1, Nappini Sara1, Grosso Salvatore2
1Siena University Obstetrics and Reproductive Medicine, Department of Neonatal Pediatrics Section, Siena, Italy
2Siena University Obstetrics and Reproductive Medicine Department of Pediatrics, Siena, Italy

Several studies have shown that small for gestational age (SGA) babies have a different hormonal profile than those born with a birth weight appropriate for gestational age (AGA). Thyroid hormones play an important role in growth and neurocognitive development. Only few studies analyzed the concentrations of thyroid-stimulating hormone (TSH) and thyroxine (T4) during fetal and extrauterine life in SGA and AGA newborns, and the existing data on the possible alterations of these hormones in postnatal life are controversial. It remains to be established whether SGA newborns have different blood concentrations of thyroid hormones as compared with AGA infants and if so, whether these findings play a role in the development of obesity, short stature, hypertension, and diabetes - disorders, already known to be related with SGA birth. It has also not yet been established whether and when substitutive therapy with levothyroxine (LT4) should be initiated in preterm and full-term SGA newborns. Further trials are needed to determine the thyroid hormone profile in both preterm and full-term SGA newborns and also to evaluate the effectiveness and safety of LT4 treatment in these infants.

Keywords: Small for gestational age, SGA, thyroid function

Franco Bagnoli, Farmeschi Laura, Nappini Sara, Grosso Salvatore. Thyroid Function in Small for Gestational Age Newborns: A Review. J Clin Res Pediatr Endocrinol. 2013; 5(1): 2-7
Manuscript Language: English
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